N-(1-ethyl-4-methyl-[1,4]diazepan-6-yl)-5-formyl-2-methoxy-4-methylamino-benzamide

Base Information

Chemical Name:N-(1-ethyl-4-methyl-[1,4]diazepan-6-yl)-5-formyl-2-methoxy-4-methylamino-benzamide
CAS No.:483304-68-3
Molecular Formula:C₁₈H₂₈N₄O₃
Molecular Weight:348.445
Hs Code.:

<i>N</i>-(1-ethyl-4-methyl-[1,4]diazepan-6-yl)-5-formyl-2-methoxy-4-methylamino-benzamide

Synonyms:N-(1-ethyl-4-methyl-[1,4]diazepan-6-yl)-5-formyl-2-methoxy-4-methylamino-benzamide

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Chemical Property of N-(1-ethyl-4-methyl-[1,4]diazepan-6-yl)-5-formyl-2-methoxy-4-methylamino-benzamide

Chemical Property:

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Technology Process of N-(1-ethyl-4-methyl-[1,4]diazepan-6-yl)-5-formyl-2-methoxy-4-methylamino-benzamide

There total 5 articles about N-(1-ethyl-4-methyl-[1,4]diazepan-6-yl)-5-formyl-2-methoxy-4-methylamino-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 206434-34-6
(RS)-6-amino-1-ethyl-4-methylhexahydro-1,4-diazepine

: 483304-02-5
5-formyl-2-methoxy-4-methylaminobenzoic acid

: 483304-68-3
N-(1-ethyl-4-methyl-[1,4]diazepan-6-yl)-5-formyl-2-methoxy-4-methylamino-benzamide

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1248/cpb.50.941

Reference yield:

: 111-37-5
N-methyl-N'-ethylethane-1,2-diamine

: 483304-68-3
N-(1-ethyl-4-methyl-[1,4]diazepan-6-yl)-5-formyl-2-methoxy-4-methylamino-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 3 h / 5 °C

1.2: 46 percent / NaBH₄ / methanol / 16 h / 20 °C

2.1: 88 percent / HBr / acetic acid / 1 h / 20 °C

3.1: EDC / CH₂Cl₂ / 20 °C

With hydrogen bromide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; dichloromethane; acetic acid;
DOI:10.1248/cpb.50.941

Reference yield:

: 106868-33-1
methyl 4-(N-methylamino)-2-methoxybenzoate

: 483304-68-3
N-(1-ethyl-4-methyl-[1,4]diazepan-6-yl)-5-formyl-2-methoxy-4-methylamino-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 65 percent / K₂CO₃ / dimethylformamide / 4 h / Heating

2.1: POCl₃ / 4 h / 80 °C

2.2: 0.62 g / aq. NaOH / methanol / 1 h / Heating

3.1: EDC / CH₂Cl₂ / 20 °C

With potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; 2.1: Vilsmeier reaction;
DOI:10.1248/cpb.50.941