4-[4-(3,4-dimethyl-phenoxy)-benzenesulfonylmethyl]-1-prop-2-ynyl-piperidine-4-carboxylic acid

Base Information

Chemical Name:4-[4-(3,4-dimethyl-phenoxy)-benzenesulfonylmethyl]-1-prop-2-ynyl-piperidine-4-carboxylic acid
CAS No.:776278-37-6
Molecular Formula:C₂₄H₂₇NO₅S
Molecular Weight:441.548
Hs Code.:

Synonyms:4-[4-(3,4-dimethyl-phenoxy)-benzenesulfonylmethyl]-1-prop-2-ynyl-piperidine-4-carboxylic acid

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Chemical Property of 4-[4-(3,4-dimethyl-phenoxy)-benzenesulfonylmethyl]-1-prop-2-ynyl-piperidine-4-carboxylic acid

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Technology Process of 4-[4-(3,4-dimethyl-phenoxy)-benzenesulfonylmethyl]-1-prop-2-ynyl-piperidine-4-carboxylic acid

There total 6 articles about 4-[4-(3,4-dimethyl-phenoxy)-benzenesulfonylmethyl]-1-prop-2-ynyl-piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 757925-78-3
4-[4-(3,4-dimethyl-phenoxy)-benzenesulfonylmethyl]-1-prop-2-ynyl-piperidine-4-carboxylic acid ethyl ester

: 776278-37-6
4-[4-(3,4-dimethyl-phenoxy)-benzenesulfonylmethyl]-1-prop-2-ynyl-piperidine-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; ethanol; at 65 ℃; for 40h;
DOI:10.1021/jm0500875

Reference yield:

: 213013-98-0
4-(iodomethyl)piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 776278-37-6
4-[4-(3,4-dimethyl-phenoxy)-benzenesulfonylmethyl]-1-prop-2-ynyl-piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 0 °C

1.2: 86 percent / dimethylformamide / 4.5 h / 0 - 20 °C

2.1: 98 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 3 h / 0 °C

3.1: 89 percent / HCl(gas) / ethyl acetate / 0.25 h / 0 °C

4.1: 82 percent / K₂CO₃ / dimethylformamide / 4 h / 20 °C

5.1: 100 percent / aq. NaOH / ethanol; tetrahydrofuran / 40 h / 65 °C

With hydrogenchloride; sodium hydroxide; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0500875

Reference yield:

: 213014-17-6
4-[4-(3,4-dimethyl-phenoxy)-phenylsulfanylmethyl]-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 776278-37-6
4-[4-(3,4-dimethyl-phenoxy)-benzenesulfonylmethyl]-1-prop-2-ynyl-piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 3 h / 0 °C

2: 89 percent / HCl(gas) / ethyl acetate / 0.25 h / 0 °C

3: 82 percent / K₂CO₃ / dimethylformamide / 4 h / 20 °C

4: 100 percent / aq. NaOH / ethanol; tetrahydrofuran / 40 h / 65 °C

With hydrogenchloride; sodium hydroxide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0500875