4-(2-(4-hydroxy-3-trifluoromethoxyphenyl)-2-oxoethoxy)-4-oxobutan-1-amine trifluoroacetate

Base Information

Chemical Name:4-(2-(4-hydroxy-3-trifluoromethoxyphenyl)-2-oxoethoxy)-4-oxobutan-1-amine trifluoroacetate
CAS No.:1174657-96-5
Molecular Formula:C₂HF₃O₂*C₁₃H₁₄F₃NO₅
Molecular Weight:435.277
Hs Code.:

Synonyms:4-(2-(4-hydroxy-3-trifluoromethoxyphenyl)-2-oxoethoxy)-4-oxobutan-1-amine trifluoroacetate

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Chemical Property of 4-(2-(4-hydroxy-3-trifluoromethoxyphenyl)-2-oxoethoxy)-4-oxobutan-1-amine trifluoroacetate

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Technology Process of 4-(2-(4-hydroxy-3-trifluoromethoxyphenyl)-2-oxoethoxy)-4-oxobutan-1-amine trifluoroacetate

There total 6 articles about 4-(2-(4-hydroxy-3-trifluoromethoxyphenyl)-2-oxoethoxy)-4-oxobutan-1-amine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1174657-95-4
2-(4-hydroxy-3-(trifluoromethoxy)phenyl)-2-oxoethyl 4-(tert-butoxycarbonylamino)butanoate

: 76-05-1
trifluoroacetic acid

: 1174657-96-5
4-(2-(4-hydroxy-3-trifluoromethoxyphenyl)-2-oxoethoxy)-4-oxobutan-1-amine trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1021/jo900139h

Reference yield:

: 690264-39-2
4-bromo-2-(trifluoromethoxy)phenol

: 1174657-96-5
4-(2-(4-hydroxy-3-trifluoromethoxyphenyl)-2-oxoethoxy)-4-oxobutan-1-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetonitrile / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C

3: phenyltrimethylammonium tribromide / methanol; dichloromethane / 20 °C

4: potassium carbonate / acetonitrile / 20 °C

5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

6: 24 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; phenyltrimethylammonium tribromide; potassium carbonate; In methanol; dichloromethane; ethyl acetate; toluene; acetonitrile; 2: Stille coupling;
DOI:10.1139/V10-143

Reference yield:

: 1174657-93-2
1-(4-benzyloxy-3-trifluoromethoxyphenyl)-2-bromoethanone

: 1174657-96-5
4-(2-(4-hydroxy-3-trifluoromethoxyphenyl)-2-oxoethoxy)-4-oxobutan-1-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

3: 24 h / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethyl acetate; acetonitrile;
DOI:10.1139/V10-143