{2-[(R)-8-(3,4-Dimethoxy-phenyl)-6-((Z)-2-[1,3]dioxolan-2-yl-vinyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethyl}-methyl-carbamic acid methyl ester

Base Information

Chemical Name:{2-[(R)-8-(3,4-Dimethoxy-phenyl)-6-((Z)-2-[1,3]dioxolan-2-yl-vinyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethyl}-methyl-carbamic acid methyl ester
CAS No.:216005-97-9
Molecular Formula:C₂₆H₃₅NO₈
Molecular Weight:489.566
Hs Code.:

Synonyms:{2-[(R)-8-(3,4-Dimethoxy-phenyl)-6-((Z)-2-[1,3]dioxolan-2-yl-vinyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethyl}-methyl-carbamic acid methyl ester

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Chemical Property of {2-[(R)-8-(3,4-Dimethoxy-phenyl)-6-((Z)-2-[1,3]dioxolan-2-yl-vinyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethyl}-methyl-carbamic acid methyl ester

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Technology Process of {2-[(R)-8-(3,4-Dimethoxy-phenyl)-6-((Z)-2-[1,3]dioxolan-2-yl-vinyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethyl}-methyl-carbamic acid methyl ester

There total 23 articles about {2-[(R)-8-(3,4-Dimethoxy-phenyl)-6-((Z)-2-[1,3]dioxolan-2-yl-vinyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethyl}-methyl-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 216005-96-8
{2-[(R)-8-(3,4-Dimethoxy-phenyl)-6-[1,3]dioxolan-2-ylethynyl-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethyl}-methyl-carbamic acid methyl ester

: 216005-97-9
{2-[(R)-8-(3,4-Dimethoxy-phenyl)-6-((Z)-2-[1,3]dioxolan-2-yl-vinyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethyl}-methyl-carbamic acid methyl ester

Guidance literature:: With hydrogen; Lindlar's catalyst; In ethyl acetate; for 2.5h; Ambient temperature;
DOI:10.1016/S0040-4039(98)01689-X

Reference yield:

: 216005-90-2
{2-[(1S,2R)-1-(3,4-Dimethoxy-phenyl)-2-hydroxy-cyclohexyl]-ethyl}-methyl-carbamic acid methyl ester

: 216005-97-9
{2-[(R)-8-(3,4-Dimethoxy-phenyl)-6-((Z)-2-[1,3]dioxolan-2-yl-vinyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethyl}-methyl-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / NaH / tetrahydrofuran / 6 h / Ambient temperature

2: 82 percent / various solvent(s) / 18 h / Heating

3: 73 percent / CrO₃, 3,5-dimethylpyrazole / CH₂Cl₂ / 2 h / -15 °C

4: 88 percent / I₂ / pyridine; CCl₄ / 20 h / Ambient temperature

5: 95 percent / i-Pr₂NH / PdCl₂(PPh₃)2, CuI / tetrahydrofuran / 0.67 h / 0 °C

6: 76 percent / p-TsOH / benzene / 12 h / Heating

7: 97 percent / H₂ / Lindlar catalyst / ethyl acetate / 2.5 h / Ambient temperature

With 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; hydrogen; iodine; sodium hydride; toluene-4-sulfonic acid; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; Lindlar's catalyst; copper(l) iodide; In tetrahydrofuran; pyridine; tetrachloromethane; dichloromethane; ethyl acetate; benzene;
DOI:10.1016/S0040-4039(98)01689-X

Reference yield:

: 10160-87-9
Propiolaldehyde diethyl acetal

: 216005-97-9
{2-[(R)-8-(3,4-Dimethoxy-phenyl)-6-((Z)-2-[1,3]dioxolan-2-yl-vinyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethyl}-methyl-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / i-Pr₂NH / PdCl₂(PPh₃)2, CuI / tetrahydrofuran / 0.67 h / 0 °C

2: 76 percent / p-TsOH / benzene / 12 h / Heating

3: 97 percent / H₂ / Lindlar catalyst / ethyl acetate / 2.5 h / Ambient temperature

With hydrogen; toluene-4-sulfonic acid; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; Lindlar's catalyst; copper(l) iodide; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1016/S0040-4039(98)01689-X