benzyl (2R,6S)-2-(benzyloxycarbonylamino)-6-(tert-butoxycarbonylamino)-7-hydroxyheptanoate

Base Information

Chemical Name:benzyl (2R,6S)-2-(benzyloxycarbonylamino)-6-(tert-butoxycarbonylamino)-7-hydroxyheptanoate
CAS No.:1104583-42-7
Molecular Formula:C₂₇H₃₆N₂O₇
Molecular Weight:500.592
Hs Code.:

Synonyms:benzyl (2R,6S)-2-(benzyloxycarbonylamino)-6-(tert-butoxycarbonylamino)-7-hydroxyheptanoate

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Chemical Property of benzyl (2R,6S)-2-(benzyloxycarbonylamino)-6-(tert-butoxycarbonylamino)-7-hydroxyheptanoate

Chemical Property:

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Technology Process of benzyl (2R,6S)-2-(benzyloxycarbonylamino)-6-(tert-butoxycarbonylamino)-7-hydroxyheptanoate

There total 9 articles about benzyl (2R,6S)-2-(benzyloxycarbonylamino)-6-(tert-butoxycarbonylamino)-7-hydroxyheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1423076-21-4
(S)-(tert-butyl) 4-((R)-5-(benzyloxy)-4-(benzyloxycarbonylamino)-5-oxopentyl)-2,2-dimethyloxazolidine-3-carboxylate

: 1104583-42-7
benzyl (2R,6S)-2-(benzyloxycarbonylamino)-6-(tert-butoxycarbonylamino)-7-hydroxyheptanoate

Guidance literature:: With toluene-4-sulfonic acid; In methanol; water; at 20 ℃; for 36h;
DOI:10.3390/molecules18011162

Reference yield:

: 167466-67-3
(R)-benzyl 2-(((benzyloxy)carbonyl)amino)pent-4-enoate

: 1104583-42-7
benzyl (2R,6S)-2-(benzyloxycarbonylamino)-6-(tert-butoxycarbonylamino)-7-hydroxyheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 3 h / Reflux

2: platinum(IV) oxide; hydrogen / ethyl acetate / 14 h / 20 °C

3: toluene-4-sulfonic acid / methanol; water / 36 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; platinum(IV) oxide; hydrogen; toluene-4-sulfonic acid; In methanol; water; ethyl acetate; toluene; 1: |Cross Metathesis;
DOI:10.3390/molecules18011162

Reference yield:

: (S)-(tert-butyl) 4-(3-hydroxyprop-1-en-1-yl)-2,2-dimethyloxazolidine-3-carboxylate

: 1104583-42-7
benzyl (2R,6S)-2-(benzyloxycarbonylamino)-6-(tert-butoxycarbonylamino)-7-hydroxyheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 3 h / Reflux

2: platinum(IV) oxide; hydrogen / ethyl acetate / 14 h / 20 °C

3: toluene-4-sulfonic acid / methanol; water / 36 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; platinum(IV) oxide; hydrogen; toluene-4-sulfonic acid; In methanol; water; ethyl acetate; toluene; 1: |Cross Metathesis;
DOI:10.3390/molecules18011162