2-((2-amino-4-fluorobenzyl)(tert-butoxycarbonyl)amino)acetic acid

Base Information

• Chemical Name: 2-((2-amino-4-fluorobenzyl)(tert-butoxycarbonyl)amino)acetic acid
• CAS No.: 1174568-45-6
• Molecular Formula: C₁₄H₁₉FN₂O₄
• Molecular Weight: 298.314
• Mol file: 1174568-45-6.mol

Synonyms:2-((2-amino-4-fluorobenzyl)(tert-butoxycarbonyl)amino)acetic acid

Chemical Property of 2-((2-amino-4-fluorobenzyl)(tert-butoxycarbonyl)amino)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((2-amino-4-fluorobenzyl)(tert-butoxycarbonyl)amino)acetic acid

There total 6 articles about 2-((2-amino-4-fluorobenzyl)(tert-butoxycarbonyl)amino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.9%

2-(tert-butoxycarbonyl-(4-fluoro-2-nitrobenzyl)amino)-acetic acid (1174568-44-5) → 2-((2-amino-4-fluorobenzyl)(tert-butoxycarbonyl)amino)acetic acid (1174568-45-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 5h;

Reference yield:

methyl 2-((2-amino-4-fluorobenzyl)(tert-butoxycarbonyl)amino)acetate → 2-((2-amino-4-fluorobenzyl)(tert-butoxycarbonyl)amino)acetic acid (1174568-45-6)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 10h;

DOI:10.1021/acsmedchemlett.5b00074

Reference yield:

2-nitro-4-fluorotoluene (446-10-6) → 2-((2-amino-4-fluorobenzyl)(tert-butoxycarbonyl)amino)acetic acid (1174568-45-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 6 h / Reflux

2.1: triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: dichloromethane / 20 °C

4.1: iron / methanol / 70 °C

4.2: 2 h / Reflux

5.1: lithium hydroxide / water; tetrahydrofuran / 10 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); iron; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/acsmedchemlett.5b00074

upstream raw materials:

2-(tert-butoxycarbonyl-(4-fluoro-2-nitrobenzyl)amino)-acetic acid

2-nitro-4-fluorotoluene

1-(bromomethyl)-4-fluoro-2-nitrobenzene

methyl 2-((4-fluoro-2-nitrobenzyl)amino)acetate