Technology Process of tert-butyl (2R,4R)-2-(4-bromophenyl)-4-hydroxypyrrolidinecarboxylate
There total 9 articles about tert-butyl (2R,4R)-2-(4-bromophenyl)-4-hydroxypyrrolidinecarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
ethanol;
at 0 ℃;
for 0.166667h;
DOI:10.1248/cpb.50.423
- Guidance literature:
-
Multi-step reaction with 4 steps
1: aq. NaOH / dioxane / 20 °C / pH 9
2: 978 mg / aq. NaOH / methanol / 1 h / 0 °C
3: 93 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
4: 88 percent / NaBH4 / ethanol / 0.17 h / 0 °C
With
sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
1,4-dioxane; methanol; ethanol; dichloromethane;
3: Swern oxidation;
DOI:10.1248/cpb.50.423
- Guidance literature:
-
Multi-step reaction with 8 steps
1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 15 h / 0 °C
2: tetrahydrofuran; H2O / -78 - 20 °C
3: 894 mg / NEt3 / CHCl3 / 0.5 h / 0 °C
4: 1.87 g / I2; H2O / tetrahydrofuran / 7.5 h / 20 °C
5: aq. NaOH / dioxane / 20 °C / pH 9
6: 978 mg / aq. NaOH / methanol / 1 h / 0 °C
7: 93 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
8: 88 percent / NaBH4 / ethanol / 0.17 h / 0 °C
With
sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; water; iodine; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water;
7: Swern oxidation;
DOI:10.1248/cpb.50.423
