5-(4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-ylamino)-4'-(trifluoromethyl)-biphenyl-2-carbonitrile

Base Information

Chemical Name:5-(4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-ylamino)-4'-(trifluoromethyl)-biphenyl-2-carbonitrile
CAS No.:1268821-80-2
Molecular Formula:C₃₀H₂₂F₃N₅O
Molecular Weight:525.533
Hs Code.:

Synonyms:5-(4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-ylamino)-4'-(trifluoromethyl)-biphenyl-2-carbonitrile

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Chemical Property of 5-(4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-ylamino)-4'-(trifluoromethyl)-biphenyl-2-carbonitrile

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Technology Process of 5-(4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-ylamino)-4'-(trifluoromethyl)-biphenyl-2-carbonitrile

There total 4 articles about 5-(4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-ylamino)-4'-(trifluoromethyl)-biphenyl-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1268822-69-0
5-(4H-1,2,4-triazol-4-ylamino)-4'-(trifluoromethyl)-biphenyl-2-carbonitrile

: 836-42-0
4-benzyloxybenzyl chloride

: 1268821-80-2
5-(4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-ylamino)-4'-(trifluoromethyl)-biphenyl-2-carbonitrile

Guidance literature:: 5-(4H-1,2,4-triazol-4-ylamino)-4'-(trifluoromethyl)-biphenyl-2-carbonitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

4-benzyloxybenzyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 18h;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1268821-80-2
5-(4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-ylamino)-4'-(trifluoromethyl)-biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / Heating; Reflux

2.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 1 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

3.2: 18 h / 20 °C

With potassium tert-butylate; sodium hydride; sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 36282-26-5
2-bromo-4-fluorobenzonitrile

: 1268821-80-2
5-(4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-ylamino)-4'-(trifluoromethyl)-biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / Heating; Reflux

2.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 1 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

3.2: 18 h / 20 °C

With potassium tert-butylate; sodium hydride; sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;