{3-[3-(4-chloro-benzylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-(2-morpholin-4-yl-ethyl)-amine

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Chemical Name:{3-[3-(4-chloro-benzylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-(2-morpholin-4-yl-ethyl)-amine
CAS No.:1386398-29-3
Molecular Formula:C₂₄H₂₆ClN₇O
Molecular Weight:463.97
Hs Code.:

Synonyms:{3-[3-(4-chloro-benzylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-(2-morpholin-4-yl-ethyl)-amine

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Chemical Property of {3-[3-(4-chloro-benzylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-(2-morpholin-4-yl-ethyl)-amine

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Technology Process of {3-[3-(4-chloro-benzylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-(2-morpholin-4-yl-ethyl)-amine

There total 7 articles about {3-[3-(4-chloro-benzylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-(2-morpholin-4-yl-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1386399-27-4
[3-[3-(4-chloro-benzylamino)-phenyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine

: 1386398-29-3
{3-[3-(4-chloro-benzylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-(2-morpholin-4-yl-ethyl)-amine

Guidance literature:: [3-[3-(4-chloro-benzylamino)-phenyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In water; pH=8;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1386398-29-3
{3-[3-(4-chloro-benzylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-(2-morpholin-4-yl-ethyl)-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -35 °C / Inert atmosphere

1.2: 2 h / -35 °C

2.1: tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 2 h / 0 °C

3.1: hydrazine / tetrahydrofuran / 0.67 h / 20 - 50 °C

4.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 1 h / 20 °C

5.1: DavePhos; sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 6 h / 100 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

6.2: pH 8

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; isopropylmagnesium chloride; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; sodium t-butanolate; DavePhos; hydrazine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 5.1: Buchwald reaction;

Reference yield:

: 1386399-15-0
3-(3-bromo-phenyl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine

: 1386398-29-3
{3-[3-(4-chloro-benzylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-(2-morpholin-4-yl-ethyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: DavePhos; sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 6 h / 100 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.2: pH 8

With triethylamine; trifluoroacetic acid; sodium t-butanolate; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 2.1: Buchwald reaction;