Technology Process of C16H24O2
There total 3 articles about C16H24O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
n-butyllithium;
With
copper(l) iodide;
In
tetrahydrofuran; hexane;
at -20 ℃;
for 0.5h;
Inert atmosphere;
(S)-2-((R)-1-benzyloxy-allyl)-oxirane;
In
tetrahydrofuran; hexane;
at -20 ℃;
for 1.5h;
Inert atmosphere;
DOI:10.1021/ol3019727
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: titanium(IV) isopropylate; Cumene hydroperoxide; D-(-)-diisopropyl tartrate / dichloromethane / 48 h / -20 °C / Molecular sieve; Inert atmosphere
2.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; mineral oil / 6 h / 20 °C / Inert atmosphere
3.1: copper(l) iodide / tetrahydrofuran; hexane / 0.5 h / -20 °C / Inert atmosphere
3.2: 1.5 h / -20 °C / Inert atmosphere
With
titanium(IV) isopropylate; copper(l) iodide; Cumene hydroperoxide; tetra-(n-butyl)ammonium iodide; sodium hydride; D-(-)-diisopropyl tartrate;
In
tetrahydrofuran; hexane; dichloromethane; mineral oil;
DOI:10.1021/ol3019727
- Guidance literature:
-
benzyl allyl ether;
With
tris-(dibenzylideneacetone)dipalladium(0); thymoquinone; C37H36F2NO2P; bis(pinacol)diborane;
In
toluene;
at 60 ℃;
for 16h;
Inert atmosphere;
hexanal;
With
(R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid;
at -40 ℃;
for 48h;
Overall yield = 79 percent;
Inert atmosphere;
DOI:10.1007/s11426-021-1134-x
