N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

Base Information

• Chemical Name: N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine
• CAS No.: 1160685-33-5
• Molecular Formula: C₁₇H₁₁BrFN₃O₄
• Molecular Weight: 420.194
• Mol file: 1160685-33-5.mol

Synonyms:N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

Chemical Property of N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine

There total 9 articles about N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.19%

ethyl N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate (1160685-34-6) → N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine (1160685-33-5)

Guidance literature:

ethyl N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate; With water; sodium hydroxide; In ethanol; at 20 ℃; for 0.5h;

With hydrogenchloride; In ethanol; water;

Reference yield:

methyl 2,6-difluorobenzoate (13671-00-6) → N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine (1160685-33-5)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: ammonium hydroxide / ethanol; water / 20 °C

3.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

4.1: bromine / dichloromethane / 0.5 h / 20 °C

5.1: tin(II) chloride dihdyrate / ethanol; acetonitrile / 3 h / Reflux

5.2: 1 h / 60 °C

6.1: boron tribromide / dichloromethane / 20 °C

7.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 20 °C

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 100 °C / Microwave irradiation

9.1: water; sodium hydroxide / ethanol / 0.5 h / 20 °C

With ammonium hydroxide; tin(II) chloride dihdyrate; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; bromine; nitric acid; boron tribromide; sodium hydride; potassium carbonate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile; mineral oil;

Reference yield:

methyl 2-amino-6-fluoro-3-nitrobenzoate (346691-23-4) → N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycine (1160685-33-5)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

2.1: bromine / dichloromethane / 0.5 h / 20 °C

3.1: tin(II) chloride dihdyrate / ethanol; acetonitrile / 3 h / Reflux

3.2: 1 h / 60 °C

4.1: boron tribromide / dichloromethane / 20 °C

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 20 °C

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 100 °C / Microwave irradiation

7.1: water; sodium hydroxide / ethanol / 0.5 h / 20 °C

With tin(II) chloride dihdyrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; bromine; boron tribromide; sodium hydride; potassium carbonate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile; mineral oil;

upstream raw materials:

ethyl N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

methyl 2,6-difluorobenzoate

methyl 2-amino-6-fluoro-3-nitrobenzoate

7-bromo-6-hydroxy-5-quinoxalinecarboxylic acid