methyl 5-phenyl-2-fluoropentanoate

Base Information

Chemical Name:methyl 5-phenyl-2-fluoropentanoate
CAS No.:1071001-81-4
Molecular Formula:C₁₂H₁₅FO₂
Molecular Weight:210.248
Hs Code.:

Synonyms:methyl 5-phenyl-2-fluoropentanoate

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Chemical Property of methyl 5-phenyl-2-fluoropentanoate

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Technology Process of methyl 5-phenyl-2-fluoropentanoate

There total 3 articles about methyl 5-phenyl-2-fluoropentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 182918-92-9
methyl 2-hydroxy-5-phenylpentanoate

: 1071001-81-4
methyl 5-phenyl-2-fluoropentanoate

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 20 ℃; for 5h;
DOI:10.1021/jm901872v

Reference yield:

: C₁₄H₁₇FO₄

: 1071001-81-4
methyl 5-phenyl-2-fluoropentanoate

Guidance literature:: With sodium bromide; In N,N-dimethyl acetamide; mineral oil; at 90 ℃;
DOI:10.1021/acs.orglett.5b00072

Reference yield:

: 637-59-2
1-Bromo-3-phenylpropane

: 1071001-81-4
methyl 5-phenyl-2-fluoropentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl acetamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

1.2: 2.5 h / 50 °C

2.1: sodium bromide / N,N-dimethyl acetamide; mineral oil / 90 °C

With sodium hydride; sodium bromide; In N,N-dimethyl acetamide; mineral oil; 2.1: |Krapcho Dealkoxycarbonylation;
DOI:10.1021/acs.orglett.5b00072