Technology Process of 7-benzyl-7H-benzo[e]pyrido[3,2-b]indole
There total 6 articles about 7-benzyl-7H-benzo[e]pyrido[3,2-b]indole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C15H10INO;
With
trifluorormethanesulfonic acid;
In
dichloromethane;
at 0 ℃;
for 1h;
Inert atmosphere;
benzylamine;
With
tris-(dibenzylideneacetone)dipalladium(0); 4,5’-bis(diphenylphosphino)-9,9’-dimethylxanthene; caesium carbonate;
In
dichloromethane; toluene;
at 110 ℃;
for 0.0833333h;
Inert atmosphere;
DOI:10.1055/s-0033-1338530
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triphenylphosphine; sodium carbonate; palladium 10% on activated carbon / 1,2-dimethoxyethane; water / 16 h / 80 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 16 h
3.1: toluene-4-sulfonic acid; sodium nitrite; potassium iodide / water; acetonitrile / 1 h / 10 - 15 °C / Inert atmosphere
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 0 °C / Inert atmosphere; Sealed tube
5.1: trifluorormethanesulfonic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere
5.2: 0.08 h / 110 °C / Inert atmosphere
With
trifluorormethanesulfonic acid; palladium 10% on activated carbon; hydrogen; sodium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; potassium iodide; sodium nitrite;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;
1.1: |Suzuki Coupling / 3.1: |Sandmeyer Reaction / 5.2: |Buchwald-Hartwig Coupling;
DOI:10.1055/s-0033-1338530
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triphenylphosphine; sodium carbonate; palladium 10% on activated carbon / 1,2-dimethoxyethane; water / 16 h / 80 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 16 h
3.1: toluene-4-sulfonic acid; sodium nitrite; potassium iodide / water; acetonitrile / 1 h / 10 - 15 °C / Inert atmosphere
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 0 °C / Inert atmosphere; Sealed tube
5.1: trifluorormethanesulfonic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere
5.2: 0.08 h / 110 °C / Inert atmosphere
With
trifluorormethanesulfonic acid; palladium 10% on activated carbon; hydrogen; sodium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; potassium iodide; sodium nitrite;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;
1.1: |Suzuki Coupling / 3.1: |Sandmeyer Reaction / 5.2: |Buchwald-Hartwig Coupling;
DOI:10.1055/s-0033-1338530
