benzyl N-[8-[4-[(2-methylpropan-2-yl)oxycarbonylimino]-6-oxo-12-oxa-3,5,7-triazabicyclo[11,4,0]heptadeca-1⁽¹³⁾,9,14,16-tetraen-7-yl]octyl]carbamate

Base Information

• Chemical Name: benzyl N-[8-[4-[(2-methylpropan-2-yl)oxycarbonylimino]-6-oxo-12-oxa-3,5,7-triazabicyclo[11,4,0]heptadeca-1⁽¹³⁾,9,14,16-tetraen-7-yl]octyl]carbamate
• CAS No.: 1448321-16-1
• Molecular Formula: C₃₄H₄₇N₅O₆
• Molecular Weight: 621.777

Synonyms:benzyl N-[8-[4-[(2-methylpropan-2-yl)oxycarbonylimino]-6-oxo-12-oxa-3,5,7-triazabicyclo[11,4,0]heptadeca-1⁽¹³⁾,9,14,16-tetraen-7-yl]octyl]carbamate

Chemical Property of benzyl N-[8-[4-[(2-methylpropan-2-yl)oxycarbonylimino]-6-oxo-12-oxa-3,5,7-triazabicyclo[11,4,0]heptadeca-1⁽¹³⁾,9,14,16-tetraen-7-yl]octyl]carbamate

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Technology Process of benzyl N-[8-[4-[(2-methylpropan-2-yl)oxycarbonylimino]-6-oxo-12-oxa-3,5,7-triazabicyclo[11,4,0]heptadeca-1⁽¹³⁾,9,14,16-tetraen-7-yl]octyl]carbamate

There total 15 articles about benzyl N-[8-[4-[(2-methylpropan-2-yl)oxycarbonylimino]-6-oxo-12-oxa-3,5,7-triazabicyclo[11,4,0]heptadeca-1⁽¹³⁾,9,14,16-tetraen-7-yl]octyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

→ benzyl N-[8-[4-[(2-methylpropan-2-yl)oxycarbonylimino]-6-oxo-12-oxa-3,5,7-triazabicyclo[11,4,0]heptadeca-1(13),9,14,16-tetraen-7-yl]octyl]carbamate (1448321-16-1)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 16h; Inert atmosphere; Reflux;

Reference yield: 30.0%

benzyl N-[8-[[N'-[(2-methylpropan-2-yl)oxycarbonyl]-N-[(2-prop-2-enoxyphenyl)methyl]carbamimidoyl]carbamoyl-prop-2-enylamino]octyl]carbamate (1448321-08-1) → benzyl N-[8-[4-[(2-methylpropan-2-yl)oxycarbonylimino]-6-oxo-12-oxa-3,5,7-triazabicyclo[11,4,0]heptadeca-1(13),9,14,16-tetraen-7-yl]octyl]carbamate (1448321-16-1)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; at 80 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ml400187w

Reference yield:

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine (207857-15-6) → benzyl N-[8-[4-[(2-methylpropan-2-yl)oxycarbonylimino]-6-oxo-12-oxa-3,5,7-triazabicyclo[11,4,0]heptadeca-1(13),9,14,16-tetraen-7-yl]octyl]carbamate (1448321-16-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 12 h / Inert atmosphere; Reflux

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 4 h / 80 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; triethylamine; In tetrahydrofuran; dichloromethane; toluene; 3: |Grubbs Olefin Metathesis;

DOI:10.1021/ml400187w

upstream raw materials:

(2-prop-2-enoxyphenyl)methanamine

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

1,3-bis(t-butoxycarbonyl)guanidine

tert-butyl N-[[(2-methylpropan-2-yl)oxycarbonylamino]-[(2-propoxyphenyl)methylamino]methyl]carbamate

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