(2-{3-[2-(2-cyanomethyl-benzyloxy)-ethoxy]-propyl}-phenyl)-phenyl-phosphinic acid methyl ester

Base Information

Chemical Name:(2-{3-[2-(2-cyanomethyl-benzyloxy)-ethoxy]-propyl}-phenyl)-phenyl-phosphinic acid methyl ester
CAS No.:240493-51-0
Molecular Formula:C₂₇H₃₀NO₄P
Molecular Weight:463.513
Hs Code.:

Synonyms:(2-{3-[2-(2-cyanomethyl-benzyloxy)-ethoxy]-propyl}-phenyl)-phenyl-phosphinic acid methyl ester

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Chemical Property of (2-{3-[2-(2-cyanomethyl-benzyloxy)-ethoxy]-propyl}-phenyl)-phenyl-phosphinic acid methyl ester

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Technology Process of (2-{3-[2-(2-cyanomethyl-benzyloxy)-ethoxy]-propyl}-phenyl)-phenyl-phosphinic acid methyl ester

There total 5 articles about (2-{3-[2-(2-cyanomethyl-benzyloxy)-ethoxy]-propyl}-phenyl)-phenyl-phosphinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 2946-61-4
phenylphosphonous acid dimethyl ester

: 240493-49-6
(2-{2-[3-(2-iodo-phenyl)-propoxy]-ethoxymethyl}-phenyl)-acetonitrile

: 240493-51-0
(2-{3-[2-(2-cyanomethyl-benzyloxy)-ethoxy]-propyl}-phenyl)-phenyl-phosphinic acid methyl ester

Guidance literature:: With palladium diacetate; at 100 ℃;
DOI:10.1021/jo990509g

Reference yield:

: 96606-95-0
3-(2-iodophenyl)propanoic acid

: 240493-51-0
(2-{3-[2-(2-cyanomethyl-benzyloxy)-ethoxy]-propyl}-phenyl)-phenyl-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / BH₃*THF

2: 84 percent / CBr₄, PPh₃

3: 74 percent / KOH

4: 48 percent / LDA

5: 89 percent

6: 82 percent / Pd(OAc)2 / 100 °C

With palladium diacetate; potassium hydroxide; borane-THF; carbon tetrabromide; triphenylphosphine; lithium diisopropyl amide;
DOI:10.1021/jo990509g

Reference yield:

: 141273-92-9
1-(3-bromopropyl)-2-iodobenzene

: 240493-51-0
(2-{3-[2-(2-cyanomethyl-benzyloxy)-ethoxy]-propyl}-phenyl)-phenyl-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / KOH

2: 48 percent / LDA

3: 89 percent

4: 82 percent / Pd(OAc)2 / 100 °C

With palladium diacetate; potassium hydroxide; lithium diisopropyl amide;
DOI:10.1021/jo990509g