tert-butyl 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Chemical Name:tert-butyl 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.:1319255-26-9
Molecular Formula:C₄₁H₅₉BrN₆O₄Si₂
Molecular Weight:836.032
Hs Code.:

tert-butyl 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate

Synonyms:tert-butyl 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Chemical Property of tert-butyl 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Technology Process of tert-butyl 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 16 articles about tert-butyl 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1319255-25-8
tert-butyl 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1319255-26-9
tert-butyl 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: With N-Bromosuccinimide; In dichloromethane; acetonitrile; at 20 ℃; for 0.5h;

Reference yield:

: 57489-77-7
5,7-dichloropyrazolo[1,5-a]pyrimidine

: 1319255-26-9
tert-butyl 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium hydroxide / 2.5 h / 85 °C / Sealed vessel

2: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,2-dimethoxyethane / 16 h / 100 °C

3: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 45 °C

4: N-iodo-succinimide / dichloromethane; acetonitrile / 1.5 h / 20 °C

5: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 15 h / 100 °C

6: N-Bromosuccinimide / dichloromethane; acetonitrile / 0.5 h / 20 °C

With ammonium hydroxide; N-Bromosuccinimide; N-iodo-succinimide; hydrogen; sodium carbonate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; palladium 10% on activated carbon; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: 57489-70-0
5,7-dihydroxypyrazolo[1,5-a]pyrimidine

: 1319255-26-9
tert-butyl 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: trichlorophosphate; N,N-dimethyl-aniline / 16 h / 0 - 60 °C / Inert atmosphere

1.2: pH ~ 8

2.1: ammonium hydroxide / 2.5 h / 85 °C / Sealed vessel

3.1: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,2-dimethoxyethane / 16 h / 100 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 45 °C

5.1: N-iodo-succinimide / dichloromethane; acetonitrile / 1.5 h / 20 °C

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 15 h / 100 °C

7.1: N-Bromosuccinimide / dichloromethane; acetonitrile / 0.5 h / 20 °C

With ammonium hydroxide; N-Bromosuccinimide; N-iodo-succinimide; hydrogen; sodium carbonate; potassium carbonate; N,N-dimethyl-aniline; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; palladium 10% on activated carbon; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; acetonitrile;