Technology Process of 4β-hydroxy-2-(S)-<(2-phenyl)ethyl>cyclopent-2-enone
There total 6 articles about 4β-hydroxy-2-(S)-<(2-phenyl)ethyl>cyclopent-2-enone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
methanol;
for 0.5h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) BuLi / 1.) Et2O, reflux, 4 h, 2.) Et2O, RT, 2 h
2: 72 percent / conc. H2SO4 / 1,2-dimethoxy-ethane; H2O / 3 h / 80 °C
3: 85 percent / basic Al2O3 B IV / diethyl ether / 18 h
4: 100 percent / pyridine / 18 h / Ambient temperature
5: 50 percent / 96 h / 30 °C / porcine pancrease lipase (PPL), pH 7
6: 100 percent / KOH / methanol / 0.5 h / Ambient temperature
With
pyridine; aluminum oxide; potassium hydroxide; n-butyllithium; sulfuric acid;
In
methanol; 1,2-dimethoxyethane; diethyl ether; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 72 percent / conc. H2SO4 / 1,2-dimethoxy-ethane; H2O / 3 h / 80 °C
2: 85 percent / basic Al2O3 B IV / diethyl ether / 18 h
3: 100 percent / pyridine / 18 h / Ambient temperature
4: 50 percent / 96 h / 30 °C / porcine pancrease lipase (PPL), pH 7
5: 100 percent / KOH / methanol / 0.5 h / Ambient temperature
With
pyridine; aluminum oxide; potassium hydroxide; sulfuric acid;
In
methanol; 1,2-dimethoxyethane; diethyl ether; water;
