2-{3-dimethylamino-5-[((S)-1-dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid methyl ester

Base Information

Chemical Name:2-{3-dimethylamino-5-[((S)-1-dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid methyl ester
CAS No.:1308662-39-6
Molecular Formula:C₂₄H₄₂N₄O₄S
Molecular Weight:482.688
Hs Code.:

2-{3-dimethylamino-5-[((S)-1-dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid methyl ester

Synonyms:2-{3-dimethylamino-5-[((S)-1-dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid methyl ester

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Chemical Property of 2-{3-dimethylamino-5-[((S)-1-dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 2-{3-dimethylamino-5-[((S)-1-dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid methyl ester

There total 10 articles about 2-{3-dimethylamino-5-[((S)-1-dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-(3-dimethylamino-5-formyl-benzyl)-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid methyl ester

: (S)-2-(3-dimethylamino-5-formyl-benzyl)-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester

: (S)-4,4,N₁,N₁-tetramethyl-pentane-1,2-diamine hydrochloride

: 1308662-39-6
2-{3-dimethylamino-5-[((S)-1-dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid methyl ester

: 1308662-43-2
2-{3-dimethylamino-5-[((S)-1-dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester

Guidance literature:: With magnesium sulfate; acetic acid; triethylamine; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 154092-71-4
((S)-1-hydroxymethyl-3,3-dimethyl-butyl)-carbamic acid tert-butyl ester

: 1308662-39-6
2-{3-dimethylamino-5-[((S)-1-dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 4 h / 0 - 20 °C / Inert atmosphere

2: pyridine / 20 h / 0 - 20 °C

3: hydrogenchloride / ethyl acetate / 20 °C / Inert atmosphere

4: magnesium sulfate; triethylamine; acetic acid / dichloromethane; ethyl acetate; methanol

With pyridine; hydrogenchloride; magnesium sulfate; acetic acid; triethylamine; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 154092-62-3
(+)-(S)-2-amino-4,4-dimethylpentanol

: 1308662-39-6
2-{3-dimethylamino-5-[((S)-1-dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

2: pyridine / 4 h / 0 - 20 °C / Inert atmosphere

3: pyridine / 20 h / 0 - 20 °C

4: hydrogenchloride / ethyl acetate / 20 °C / Inert atmosphere

5: magnesium sulfate; triethylamine; acetic acid / dichloromethane; ethyl acetate; methanol

With pyridine; hydrogenchloride; magnesium sulfate; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;