(2R,3S)-3-(tert-butyldiphenylsilyloxy)-2-(3′,4′-dimethoxyphenyl)piperidine

Base Information

Chemical Name:(2R,3S)-3-(tert-butyldiphenylsilyloxy)-2-(3′,4′-dimethoxyphenyl)piperidine
CAS No.:1395820-62-8
Molecular Formula:C₂₉H₃₇NO₃Si
Molecular Weight:475.703
Hs Code.:

Synonyms:(2R,3S)-3-(tert-butyldiphenylsilyloxy)-2-(3′,4′-dimethoxyphenyl)piperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-3-(tert-butyldiphenylsilyloxy)-2-(3′,4′-dimethoxyphenyl)piperidine

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Technology Process of (2R,3S)-3-(tert-butyldiphenylsilyloxy)-2-(3′,4′-dimethoxyphenyl)piperidine

There total 5 articles about (2R,3S)-3-(tert-butyldiphenylsilyloxy)-2-(3′,4′-dimethoxyphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1395819-89-2
C₂₉H₃₇NO₄Si

: 1395820-62-8
(2R,3S)-3-(tert-butyldiphenylsilyloxy)-2-(3′,4′-dimethoxyphenyl)piperidine

Guidance literature:: With indium; ammonium chloride; zinc; In ethanol; water; for 4h; Reflux;
DOI:10.1021/jo3011914

Reference yield:

: 1395819-03-0
(3S)-3-tert-butyldiphenylsilyloxy-3,4,5,6-tetrahydropyridine N-oxide

: 1395820-62-8
(2R,3S)-3-(tert-butyldiphenylsilyloxy)-2-(3′,4′-dimethoxyphenyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: zinc; indium; ammonium chloride / ethanol; water / 4 h / Reflux

With indium; ammonium chloride; zinc; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jo3011914

Reference yield:

: 1067244-41-0
(2S)-2-(tert-butyldiphenylsilyloxy)pentane-1,5-diol

: 1395820-62-8
(2R,3S)-3-(tert-butyldiphenylsilyloxy)-2-(3′,4′-dimethoxyphenyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: p-toluenesulfonyl chloride / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: triethylamine; hydroxylamine hydrochloride / 4 h / Reflux; Inert atmosphere

3.1: manganese(IV) oxide / dichloromethane / 2 h / 0 °C / Inert atmosphere

4.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

5.1: zinc; indium; ammonium chloride / ethanol; water / 4 h / Reflux

With manganese(IV) oxide; indium; hydroxylamine hydrochloride; ammonium chloride; triethylamine; p-toluenesulfonyl chloride; zinc; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jo3011914