2-[4-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]oxyphenyl]acetic acid

Base Information

Chemical Name:2-[4-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]oxyphenyl]acetic acid
CAS No.:1024033-63-3
Molecular Formula:C₂₃H₂₈N₂O₄S
Molecular Weight:428.552
Hs Code.:

Synonyms:2-[4-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]oxyphenyl]acetic acid

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Chemical Property of 2-[4-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]oxyphenyl]acetic acid

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Technology Process of 2-[4-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]oxyphenyl]acetic acid

There total 6 articles about 2-[4-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]oxyphenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₃₀N₂O₄S

: 1024033-63-3
2-[4-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]oxyphenyl]acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 25 ℃; for 3h;
DOI:10.1021/jm300592r

Reference yield:

: 1003872-51-2
2,6-dichloro-N-cyclohexyl-pyridine-3-carboxamide

: 1024033-63-3
2-[4-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]oxyphenyl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 25 °C

1.2: 2 h / 25 °C

2.1: potassium carbonate / propyl cyanide / 2 h / 170 °C / Microwave irradiation

3.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 25 °C

With water; sodium hexamethyldisilazane; potassium carbonate; lithium hydroxide; In tetrahydrofuran; propyl cyanide; N,N-dimethyl-formamide;
DOI:10.1021/jm300592r

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1024033-63-3
2-[4-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]oxyphenyl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 25 °C

2.1: dichloromethane / 15 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 25 °C

3.2: 2 h / 25 °C

4.1: potassium carbonate / propyl cyanide / 2 h / 170 °C / Microwave irradiation

5.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 25 °C

With thionyl chloride; water; sodium hexamethyldisilazane; potassium carbonate; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; propyl cyanide; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm300592r