1-[6-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-hex-2-ynyl]-cyclohexanol

Base Information

Chemical Name:1-[6-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-hex-2-ynyl]-cyclohexanol
CAS No.:1309387-86-7
Molecular Formula:C₁₈H₃₄O₃Si
Molecular Weight:326.552
Hs Code.:

Synonyms:1-[6-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-hex-2-ynyl]-cyclohexanol

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Chemical Property of 1-[6-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-hex-2-ynyl]-cyclohexanol

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Technology Process of 1-[6-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-hex-2-ynyl]-cyclohexanol

There total 5 articles about 1-[6-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-hex-2-ynyl]-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 52329-71-2
1-hydroxycyclohexanecarboxaldehyde

: 61362-77-4
5-[tert-butyldimethylsilyloxy]pent-1-yne

: 1309387-86-7
1-[6-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-hex-2-ynyl]-cyclohexanol

Guidance literature:: 5-[tert-butyldimethylsilyloxy]pent-1-yne; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1.5h; Inert atmosphere;

1-hydroxycyclohexanecarboxaldehyde; In tetrahydrofuran; at -78 - 20 ℃; for 2.25h; Inert atmosphere;
DOI:10.1021/ol201102x

Reference yield:

: 5849-22-9
2-(1-hydroxycyclohexyl)-1,3-dithiane

: 1309387-86-7
1-[6-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-hex-2-ynyl]-cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; calcium carbonate; mercury dichloride / tetrahydrofuran; acetonitrile / 48 h / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

2.2: 2.25 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; water; calcium carbonate; mercury dichloride; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ol201102x

Reference yield:

: 5390-04-5
pent-1-yn-5-ol

: 1309387-86-7
1-[6-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-hex-2-ynyl]-cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

2.2: 2.25 h / -78 - 20 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol201102x