methyl 3-methyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

Base Information

Chemical Name:methyl 3-methyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate
CAS No.:1265400-63-2
Molecular Formula:C₂₄H₃₃N₃O₂
Molecular Weight:395.545
Hs Code.:

Synonyms:methyl 3-methyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

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Chemical Property of methyl 3-methyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

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Technology Process of methyl 3-methyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

There total 7 articles about methyl 3-methyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 513-48-4,52152-71-3
2-butyl iodide

: 1265400-26-7
methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate

: 1265400-63-2
methyl 3-methyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at -15 ℃; for 0.25h;

2-butyl iodide; In tetrahydrofuran; N,N-dimethyl-formamide; at -15 - 20 ℃; for 3h;

Reference yield:

: 162498-52-4
(2,4-dichloro-6-methylpyrimidin-5-yl)acetic acid methyl ester

: 1265400-63-2
methyl 3-methyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3.5 h / Reflux

2.1: tetrahydrofuran / 1 h / 110 °C / Sealed tube; Microwave irradiation

3.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -15 °C

3.2: 3 h / -15 - 20 °C

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 10420-33-4
dimethyl 2-acetylsuccinate

: 1265400-63-2
methyl 3-methyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate / methanol / 18 h / Reflux

1.2: 0 °C

2.1: water; chloroacetic acid / 24 h / Reflux

3.1: thionyl chloride / 12 h / 0 °C / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 115 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3.5 h / Reflux

6.1: tetrahydrofuran / 1 h / 110 °C / Sealed tube; Microwave irradiation

7.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -15 °C

7.2: 3 h / -15 - 20 °C

With thionyl chloride; water; sodium methylate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; chloroacetic acid; lithium hexamethyldisilazane; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;