5-phenylpentyl N-methyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

Base Information

Chemical Name:5-phenylpentyl N-methyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate
CAS No.:1439366-92-3
Molecular Formula:C₁₇H₂₃NO₄
Molecular Weight:305.374
Hs Code.:

Synonyms:5-phenylpentyl N-methyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

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Chemical Property of 5-phenylpentyl N-methyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

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Technology Process of 5-phenylpentyl N-methyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

There total 5 articles about 5-phenylpentyl N-methyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1439367-96-0
(2R,3S)-3-hydroxy-2-[methyl-(5-phenylpentoxycarbonyl)-amino]-butanoic acid

: 1439366-92-3
5-phenylpentyl N-methyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm400739u

Reference yield:

: 226067-37-4
(2R,3S)-3-benzyloxy-2-[tert-butoxycarbonyl-(methyl)-amino]-butanoic acid

: 1439366-92-3
5-phenylpentyl N-methyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; palladium 10% on activated carbon / ethanol / 60 °C / 750.08 Torr

2.1: trifluoroacetic acid / 0.25 h / 0 °C

3.1: dmap / dichloromethane / 15 h / 20 °C / Inert atmosphere

3.2: 15 h / 20 °C

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With dmap; palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1021/jm400739u

Reference yield:

: 170872-87-4
(2R,3S)-2-[tert-butoxycarbonyl-(methyl)-amino]-3-hydroxy-butanoic acid

: 1439366-92-3
5-phenylpentyl N-methyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / 0.25 h / 0 °C

2.1: dmap / dichloromethane / 15 h / 20 °C / Inert atmosphere

2.2: 15 h / 20 °C

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm400739u