(2S,3R)-3-(2,4-dichlorophenyl)-2-ethyl-4-nitrobutyraldehyde

Base Information

• Chemical Name: (2S,3R)-3-(2,4-dichlorophenyl)-2-ethyl-4-nitrobutyraldehyde
• CAS No.: 1021394-84-2
• Molecular Formula: C₁₂H₁₃Cl₂NO₃
• Molecular Weight: 290.146
• Mol file: 1021394-84-2.mol

Synonyms:(2S,3R)-3-(2,4-dichlorophenyl)-2-ethyl-4-nitrobutyraldehyde

Chemical Property of (2S,3R)-3-(2,4-dichlorophenyl)-2-ethyl-4-nitrobutyraldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-3-(2,4-dichlorophenyl)-2-ethyl-4-nitrobutyraldehyde

There total 4 articles about (2S,3R)-3-(2,4-dichlorophenyl)-2-ethyl-4-nitrobutyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trans-2,4-dichloro-β-nitrostyrene (18984-21-9,34209-97-7) + butyraldehyde (123-72-8) → (2S,3R)-3-(2,4-dichlorophenyl)-2-ethyl-4-nitrobutyraldehyde (1021394-84-2)

Guidance literature:

With : H-D-Pro-Pro-Glu supported on polyethyleneglycol-polystyrene (TentaGel resin); In chloroform; isopropyl alcohol; at -15 ℃; for 22h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/adsc.201100118

Reference yield: 97.0%

2,4-dichloro-1-(2-nitrovinyl)benzene (34209-97-7,18984-21-9) + butyraldehyde (123-72-8) → (2S,3R)-3-(2,4-dichlorophenyl)-2-ethyl-4-nitrobutyraldehyde (1021394-84-2)

Guidance literature:

With 4-methyl-morpholine; H-D-Pro-L-Pro-L-Glu-NH₂*TFA; In chloroform; isopropyl alcohol; at 20 ℃; optical yield given as %ee;

DOI:10.1002/chem.200901021

Reference yield:

trans-2,4-dichloro-β-nitrostyrene (18984-21-9,34209-97-7) + butyraldehyde (123-72-8) → (2S,3R)-3-(2,4-dichlorophenyl)-2-ethyl-4-nitrobutyraldehyde (1021394-84-2) + (2R,3S)-3-(2,4-dichlorophenyl)-2-ethyl-4-nitrobutyraldehyde

Guidance literature:

With L-proline; In chloroform; isopropyl alcohol; at 24 ℃; for 6h; Reagent/catalyst; enantioselective reaction;

DOI:10.1002/adsc.201701627

upstream raw materials:

trans-2,4-dichloro-β-nitrostyrene

butyraldehyde

2,4-dichloro-1-(2-nitrovinyl)benzene