ethyl (2E)-3-(2-amino-4-{[cis-4-(2-amino-2-oxoethoxy)cyclohexyl]amino}-6-methylpyrimidin-5-yl)acrylate

Base Information

Chemical Name:ethyl (2E)-3-(2-amino-4-{[cis-4-(2-amino-2-oxoethoxy)cyclohexyl]amino}-6-methylpyrimidin-5-yl)acrylate
CAS No.:1431626-41-3
Molecular Formula:C₁₈H₂₇N₅O₄
Molecular Weight:377.443
Hs Code.:

Synonyms:ethyl (2E)-3-(2-amino-4-{[cis-4-(2-amino-2-oxoethoxy)cyclohexyl]amino}-6-methylpyrimidin-5-yl)acrylate

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Chemical Property of ethyl (2E)-3-(2-amino-4-{[cis-4-(2-amino-2-oxoethoxy)cyclohexyl]amino}-6-methylpyrimidin-5-yl)acrylate

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Technology Process of ethyl (2E)-3-(2-amino-4-{[cis-4-(2-amino-2-oxoethoxy)cyclohexyl]amino}-6-methylpyrimidin-5-yl)acrylate

There total 7 articles about ethyl (2E)-3-(2-amino-4-{[cis-4-(2-amino-2-oxoethoxy)cyclohexyl]amino}-6-methylpyrimidin-5-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1431626-40-2
2-({cis-4-[(2-amino-5-bromo-6-methylpyrimidin-4-yl)amino]cyclohexyl}oxy)acetamide

: 140-88-5,9003-32-1
ethyl acrylate

: 1431626-41-3
ethyl (2E)-3-(2-amino-4-{[cis-4-(2-amino-2-oxoethoxy)cyclohexyl]amino}-6-methylpyrimidin-5-yl)acrylate

Guidance literature:: 2-({cis-4-[(2-amino-5-bromo-6-methylpyrimidin-4-yl)amino]cyclohexyl}oxy)acetamide; ethyl acrylate; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; at 130 ℃; Inert atmosphere; Sealed tube;

In N,N-dimethyl-formamide; at 130 ℃; Inert atmosphere; Sealed tube;
DOI:10.1016/j.bmcl.2013.02.020

Reference yield:

: 1431626-38-8
methyl [(cis-4-{[5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)-6-methylpyrimidin-4-yl]amino}cyclohexyl)oxy]acetate

: 1431626-41-3
ethyl (2E)-3-(2-amino-4-{[cis-4-(2-amino-2-oxoethoxy)cyclohexyl]amino}-6-methylpyrimidin-5-yl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / water; methanol / 2 h / 20 °C

2.1: water / ethanol / Reflux

2.2: 72 h / 20 °C / Sealed tube

3.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 130 °C / Inert atmosphere; Sealed tube

3.2: 130 °C / Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; water; triethylamine; In methanol; ethanol; water;
DOI:10.1016/j.bmcl.2013.02.020

Reference yield:

: C₂₃H₃₃BrN₄O₃

: 1431626-41-3
ethyl (2E)-3-(2-amino-4-{[cis-4-(2-amino-2-oxoethoxy)cyclohexyl]amino}-6-methylpyrimidin-5-yl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 20 °C

2.1: ammonia / water; methanol / 2 h / 20 °C

3.1: water / ethanol / Reflux

3.2: 72 h / 20 °C / Sealed tube

4.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 130 °C / Inert atmosphere; Sealed tube

4.2: 130 °C / Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; water; triethylamine; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1016/j.bmcl.2013.02.020