3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-(2-morpholin-4-yl-ethoxy)-phenylamine

Base Information

• Chemical Name: 3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-(2-morpholin-4-yl-ethoxy)-phenylamine
• CAS No.: 887938-48-9
• Molecular Formula: C₁₆H₂₁BrN₄O₂
• Molecular Weight: 381.272

Synonyms:3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-(2-morpholin-4-yl-ethoxy)-phenylamine

Chemical Property of 3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-(2-morpholin-4-yl-ethoxy)-phenylamine

Chemical Property:

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Technology Process of 3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-(2-morpholin-4-yl-ethoxy)-phenylamine

There total 1 articles about 3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-(2-morpholin-4-yl-ethoxy)-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H23BrN4O3 (1190953-94-6) → 3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-(2-morpholin-4-yl-ethoxy)-phenylamine (887938-48-9)

Guidance literature:

With water; sodium hydroxide; In methanol; at 150 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2009.07.073

Reference yield: 21.0%

3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-(2-morpholin-4-yl-ethoxy)-phenylamine (887938-48-9) + cyclopentanecarboxylic acid (3400-45-1) → cyclopentanecarboxylic acid [3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-(2-morpholin-4-yl-ethoxy)-phenyl]-amide

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-(2-morpholin-4-yl-ethoxy)-phenylamine (887938-48-9) + p-chlorphenylisocyanate (104-12-1) → 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-(2-morpholin-4-yl-ethoxy)-phenyl]-3-(4-chloro-phenyl)-urea

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2009.07.073

upstream raw materials:

C₁₈H₂₃BrN₄O₃

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