L-homoalanine-4-yl(methyl)phosphinic acid hydrochloride

Base Information

• Chemical Name: L-homoalanine-4-yl(methyl)phosphinic acid hydrochloride
• CAS No.: 73777-49-8
• Molecular Formula: C₅H₁₂NO₄P*ClH
• Molecular Weight: 217.589
• Mol file: 73777-49-8.mol

Synonyms:L-homoalanine-4-yl(methyl)phosphinic acid hydrochloride

Chemical Property of L-homoalanine-4-yl(methyl)phosphinic acid hydrochloride

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-homoalanine-4-yl(methyl)phosphinic acid hydrochloride

There total 2 articles about L-homoalanine-4-yl(methyl)phosphinic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

4-(hydroxymethylphosphinyl)-2-oxobutanoic acid (79778-02-2) → L-homoalanine-4-yl(methyl)phosphinic acid hydrochloride (73777-49-8)

Guidance literature:

With ammonium hydroxide; D-glucose; NAD; ammonium chloride; sodium chloride; diothiothreitol; for 144h; Ambient temperature; glutamate dehydrogenase, glucose dehydrogenase, ammonium phosphate buffer (pH 7.5);

DOI:10.1039/P19950000967

Reference yield:

2-acetylamino-4-(hydroxy(methyl)phosphinyl)butanoic acid (73634-73-8) → L-homoalanine-4-yl(methyl)phosphinic acid hydrochloride (73777-49-8) + D-phosphinothricin hydrochloride (104361-75-3)

Guidance literature:

With hydrogenchloride; pyrographite; for 16h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1021/jo00005a024

Reference yield: 93.0%

L-homoalanine-4-yl(methyl)phosphinic acid hydrochloride (73777-49-8) → L-phosphinothricin (35597-44-5,53369-07-6)

Guidance literature:

With ammonia; In methanol; water; at -5 - 60 ℃; for 3.66667h; Solvent; Temperature; Reagent/catalyst;

upstream raw materials:

2-acetylamino-4-(hydroxy(methyl)phosphinyl)butanoic acid

4-(hydroxymethylphosphinyl)-2-oxobutanoic acid

Downstream raw materials:

L-phosphinothricin