2-[4-chloro-1-(4-fluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

Base Information

Chemical Name:2-[4-chloro-1-(4-fluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole
CAS No.:1262106-97-7
Molecular Formula:C₂₃H₂₁ClFN₃O₃
Molecular Weight:441.889
Hs Code.:

Synonyms:2-[4-chloro-1-(4-fluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

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Chemical Property of 2-[4-chloro-1-(4-fluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

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Technology Process of 2-[4-chloro-1-(4-fluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

There total 3 articles about 2-[4-chloro-1-(4-fluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1262106-98-8
N'-[5-chloro-2-(4-fluorophenyl)pentanoyl]-3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide

: 1262106-97-7
2-[4-chloro-1-(4-fluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

Guidance literature:: With tetrachloromethane; triphenylphosphine; In acetonitrile; at 80 ℃; for 2h;

Reference yield:

: 516483-14-0
5-chloro-2-(4-fluorophenyl)pentanoic acid

: 1262106-97-7
2-[4-chloro-1-(4-fluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / acetonitrile / 16 h / 20 °C

2: triphenylphosphine; tetrachloromethane / acetonitrile / 2 h / 80 °C

With tetrachloromethane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; benzotriazol-1-ol; In acetonitrile;

Reference yield:

: 405-50-5
p-Fluorophenylacetic acid

: 1262106-97-7
2-[4-chloro-1-(4-fluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C

1.2: 16 h / 20 °C

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / acetonitrile / 16 h / 20 °C

3.1: triphenylphosphine; tetrachloromethane / acetonitrile / 2 h / 80 °C

With tetrachloromethane; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; benzotriazol-1-ol; In tetrahydrofuran; hexane; acetonitrile;