ethyl (4R,5S)-2,2-dimethyl-5-[2-(4-nitrophenoxy)ethyl]-1,3-dioxolane-4-carboxylate

Base Information

Chemical Name:ethyl (4R,5S)-2,2-dimethyl-5-[2-(4-nitrophenoxy)ethyl]-1,3-dioxolane-4-carboxylate
CAS No.:501648-82-4
Molecular Formula:C₁₆H₂₁NO₇
Molecular Weight:339.345
Hs Code.:

Synonyms:ethyl (4R,5S)-2,2-dimethyl-5-[2-(4-nitrophenoxy)ethyl]-1,3-dioxolane-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (4R,5S)-2,2-dimethyl-5-[2-(4-nitrophenoxy)ethyl]-1,3-dioxolane-4-carboxylate

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Technology Process of ethyl (4R,5S)-2,2-dimethyl-5-[2-(4-nitrophenoxy)ethyl]-1,3-dioxolane-4-carboxylate

There total 5 articles about ethyl (4R,5S)-2,2-dimethyl-5-[2-(4-nitrophenoxy)ethyl]-1,3-dioxolane-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 501648-81-3
ethyl (4R,5S)-5-(2-iodoethyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

: 824-78-2
4-nitrophenol sodium salt

: 501648-82-4
ethyl (4R,5S)-2,2-dimethyl-5-[2-(4-nitrophenoxy)ethyl]-1,3-dioxolane-4-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 50 ℃; for 16h;
DOI:10.1002/1522-2675(200210)85:10<3090::AID-HLCA3090>3.0.CO;2-8

Reference yield:

: 501648-79-9
ethyl (4R,5S)-5-(2-benzyloxyethyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

: 501648-82-4
ethyl (4R,5S)-2,2-dimethyl-5-[2-(4-nitrophenoxy)ethyl]-1,3-dioxolane-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / H₂ / 10 percent Pd/C / ethanol / 18 h / 20 °C

2: 90 percent / PPh₃; 1H-imidazole; I₂ / CH₂Cl₂ / 2 h / 20 °C

3: 89 percent / dimethylformamide / 16 h / 50 °C

With 1H-imidazole; hydrogen; iodine; triphenylphosphine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/1522-2675(200210)85:10<3090::AID-HLCA3090>3.0.CO;2-8

Reference yield:

: 70542-83-5
ethyl (2E)-5-(benzyloxy)pent-2-enoate

: 501648-82-4
ethyl (4R,5S)-2,2-dimethyl-5-[2-(4-nitrophenoxy)ethyl]-1,3-dioxolane-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / NaHCO3; MeSO2NH2; AD-mix-α / H2O; 2-methyl-propan-2-ol / 24 h / 0 °C

2: 98 percent / TsOH / acetone / 1.5 h / 20 °C

3: 99 percent / H₂ / 10 percent Pd/C / ethanol / 18 h / 20 °C

4: 90 percent / PPh₃; 1H-imidazole; I₂ / CH₂Cl₂ / 2 h / 20 °C

5: 89 percent / dimethylformamide / 16 h / 50 °C

With 1H-imidazole; AD-mix-α; methanesulfonamide; hydrogen; iodine; sodium hydrogencarbonate; triphenylphosphine; palladium on activated charcoal; toluene-4-sulfonic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1002/1522-2675(200210)85:10<3090::AID-HLCA3090>3.0.CO;2-8