8-bromo-N-[(2-chloro-5-methoxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide

Base Information

• Chemical Name: 8-bromo-N-[(2-chloro-5-methoxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide
• CAS No.: 1254309-00-6
• Molecular Formula: C₁₆H₁₀BrClF₃N₃O₄S
• Molecular Weight: 512.691
• Mol file: 1254309-00-6.mol

Synonyms:8-bromo-N-[(2-chloro-5-methoxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide

Chemical Property of 8-bromo-N-[(2-chloro-5-methoxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-bromo-N-[(2-chloro-5-methoxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide

There total 3 articles about 8-bromo-N-[(2-chloro-5-methoxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid (1228376-74-6) + 2-chloro-5-methoxy-benzene sulfonamide → 8-bromo-N-[(2-chloro-5-methoxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (1254309-00-6)

Guidance literature:

8-bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; tert-butyl alcohol; for 0.25h;

2-chloro-5-methoxy-benzene sulfonamide; In dichloromethane; tert-butyl alcohol; at 20 - 25 ℃;

Reference yield:

3-bromo-5-trifluoromethyl-pyridin-2-ylamine (79456-30-7) → 8-bromo-N-[(2-chloro-5-methoxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (1254309-00-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,2-dimethoxyethane

2: sodium hydroxide / ethanol; water

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tert-butyl alcohol; dichloromethane

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2017.02.029

Reference yield:

8-bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester (1254309-85-7) → 8-bromo-N-[(2-chloro-5-methoxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (1254309-00-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tert-butyl alcohol; dichloromethane

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; dichloromethane; water; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2017.02.029

upstream raw materials:

8-bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid

3-bromo-5-trifluoromethyl-pyridin-2-ylamine

8-bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester