N-[(2S)-1-fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine

Base Information

Chemical Name:N-[(2S)-1-fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine
CAS No.:1373348-53-8
Molecular Formula:C₁₃H₁₆FN
Molecular Weight:207.259
Hs Code.:

N-[(2S)-1-fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-<sup>(2)</sup>H<sub>2</sub>)prop-2-yn-1-amine

Synonyms:N-[(2S)-1-fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine

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Chemical Property of N-[(2S)-1-fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine

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Technology Process of N-[(2S)-1-fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine

There total 3 articles about N-[(2S)-1-fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1373348-58-3
(2S)-2-{methyl[(1,1-⁽²⁾H₂)prop-2-yn-1-yl]amino}-3-phenyl-propan-1-ol

: 1373348-53-8
N-[(2S)-1-fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine

: N-[(2R)-2-fluoro-3-phenylpropyl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine

Guidance literature:: With Nonafluorobutanesulfonyl fluoride; triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield:

: 2566-30-5
N-Methyl-L-phenylalanine

: 1373348-53-8
N-[(2S)-1-fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -10 °C / Reflux

1.2: -40 - 20 °C

2.1: potassium carbonate / tetrahydrofuran / 20 °C

3.1: Nonafluorobutanesulfonyl fluoride; triethylamine; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 24 h / 20 °C

With lithium aluminium tetrahydride; Nonafluorobutanesulfonyl fluoride; potassium carbonate; triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran;

Reference yield:

: 84773-29-5
(S)-(+)-2-(N-methylamino)-3-phenylpropanol

: 1373348-53-8
N-[(2S)-1-fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrahydrofuran / 20 °C

2: Nonafluorobutanesulfonyl fluoride; triethylamine; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 24 h / 20 °C

With Nonafluorobutanesulfonyl fluoride; potassium carbonate; triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran;