1-(2-hydroxy-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 1-(2-hydroxy-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione
• CAS No.: 101527-47-3
• Molecular Formula: C₂₈H₂₈N₂O₆
• Molecular Weight: 488.54
• Mol file: 101527-47-3.mol

Synonyms:1-(2-hydroxy-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione

Chemical Property of 1-(2-hydroxy-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-hydroxy-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione

There total 3 articles about 1-(2-hydroxy-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5'-O-trityluridine dialdehyde (90145-83-8,90193-50-3,90193-51-4) → 1-(2-hydroxy-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione (101527-47-3)

Guidance literature:

With sodium tetrahydroborate; In ethanol; water; at 20 ℃; for 16h;

DOI:10.1039/P29840000261

Reference yield:

(R)-2-[(R)-1-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-oxo-ethoxy]-3-trityloxy-propionaldehyde → 1-(2-hydroxy-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione (101527-47-3)

Guidance literature:

With sodium tetrahydroborate; In 1,4-dioxane; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/hlca.201300289

Reference yield:

5'-O-trityluridine (6554-10-5) → 1-(2-hydroxy-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione (101527-47-3)

Guidance literature:

With sodium tetrahydroborate; sodium periodate; Yield given. Multistep reaction; 1.) dioxane, H₂O, r.t., 18 h, 2.) 15 min;

DOI:10.1002/hlca.19920750209

upstream raw materials:

5'-O-trityluridine dialdehyde

5'-O-trityluridine

Downstream raw materials:

2-[2-azido-1-(3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)ethoxy]-3-(triphenylmethoxy)propyl benzoate

1-(2-azido-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione

1-(2-azido-1-{[1-(prop-2-yn-1-yloxy)-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione

1-{6,7,9,10-tetrahydro-7-[ (triphenylmethoxy)methyl]-4H-[1,2,3]triazolo[5,1-f][1,4,7]dioxazonin-9-yl}pyrimidine-2,4(1H,3H)-dione