(S)-2-[Methyl-((S)-2-pyrrolidin-2-yl-acetyl)-amino]-3-phenyl-propionamide

Base Information

Chemical Name:(S)-2-[Methyl-((S)-2-pyrrolidin-2-yl-acetyl)-amino]-3-phenyl-propionamide
CAS No.:157973-98-3
Molecular Formula:C₁₆H₂₃N₃O₂
Molecular Weight:289.378
Hs Code.:

Synonyms:(S)-2-[Methyl-((S)-2-pyrrolidin-2-yl-acetyl)-amino]-3-phenyl-propionamide

Suppliers and Price of (S)-2-[Methyl-((S)-2-pyrrolidin-2-yl-acetyl)-amino]-3-phenyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-[Methyl-((S)-2-pyrrolidin-2-yl-acetyl)-amino]-3-phenyl-propionamide

Chemical Property:

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Technology Process of (S)-2-[Methyl-((S)-2-pyrrolidin-2-yl-acetyl)-amino]-3-phenyl-propionamide

There total 3 articles about (S)-2-[Methyl-((S)-2-pyrrolidin-2-yl-acetyl)-amino]-3-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 157973-97-2
N-Cbz-β-HProN(Me)PheNH2

: 157973-98-3
(S)-2-[Methyl-((S)-2-pyrrolidin-2-yl-acetyl)-amino]-3-phenyl-propionamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 30h; under 760 Torr;
DOI:10.1021/jm00037a005

Reference yield:

: 56633-73-9
(S)-2-(1-((benzyloxy)carbonyl)pyrrolidine-2-yl)acetic acid

: 157973-98-3
(S)-2-[Methyl-((S)-2-pyrrolidin-2-yl-acetyl)-amino]-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / NMM, N-hydroxybenzotriazole hydrate, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 120 h / Ambient temperature

2: 92 percent / H₂ / 10percent Pd/C / ethanol / 30 h / 760 Torr

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00037a005

Reference yield:

: N²-methyl-L-phenylalaninamide hydrochloride

: 157973-98-3
(S)-2-[Methyl-((S)-2-pyrrolidin-2-yl-acetyl)-amino]-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / NMM, N-hydroxybenzotriazole hydrate, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 120 h / Ambient temperature

2: 92 percent / H₂ / 10percent Pd/C / ethanol / 30 h / 760 Torr

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00037a005