1-[3-(8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-5-(methylsulfonyl)phenyl]-3-(R)-1-pyrrolidin-2-ylmethyl-urea

Base Information

Chemical Name:1-[3-(8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-5-(methylsulfonyl)phenyl]-3-(R)-1-pyrrolidin-2-ylmethyl-urea
CAS No.:1044271-43-3
Molecular Formula:C₂₃H₃₂N₈O₄S
Molecular Weight:516.624
Hs Code.:

Synonyms:1-[3-(8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-5-(methylsulfonyl)phenyl]-3-(R)-1-pyrrolidin-2-ylmethyl-urea

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Chemical Property of 1-[3-(8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-5-(methylsulfonyl)phenyl]-3-(R)-1-pyrrolidin-2-ylmethyl-urea

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Technology Process of 1-[3-(8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-5-(methylsulfonyl)phenyl]-3-(R)-1-pyrrolidin-2-ylmethyl-urea

There total 1 articles about 1-[3-(8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-5-(methylsulfonyl)phenyl]-3-(R)-1-pyrrolidin-2-ylmethyl-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1044272-52-7
(R)-2-[3-[3-(8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-5-(methylsulfonyl)phenyl]ureidomethyl]pyrrolidine-1-carboxylic acid tert-butyl ester

: 1044271-43-3
1-[3-(8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-5-(methylsulfonyl)phenyl]-3-(R)-1-pyrrolidin-2-ylmethyl-urea

Guidance literature:: (R)-2-[3-[3-(8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-5-(methylsulfonyl)phenyl]ureidomethyl]pyrrolidine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In methanol; water; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 27.0%

: 1044271-43-3
1-[3-(8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-5-(methylsulfonyl)phenyl]-3-(R)-1-pyrrolidin-2-ylmethyl-urea

: 120-92-3
cyclopentanone

: 1044271-51-3
C₂₈H₄₀N₈O₄S

Guidance literature:: 1-[3-(8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-5-(methylsulfonyl)phenyl]-3-(R)-1-pyrrolidin-2-ylmethyl-urea; cyclopentanone; With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;