(R)-dibenzyl 2-[(S)-1-(tert-butanesulfinamido)-2,2,2-trifluoroethyl]malonate

Base Information

Chemical Name:(R)-dibenzyl 2-[(S)-1-(tert-butanesulfinamido)-2,2,2-trifluoroethyl]malonate
CAS No.:1372420-85-3
Molecular Formula:C₂₃H₂₆F₃NO₅S
Molecular Weight:485.524
Hs Code.:

Synonyms:(R)-dibenzyl 2-[(S)-1-(tert-butanesulfinamido)-2,2,2-trifluoroethyl]malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-dibenzyl 2-[(S)-1-(tert-butanesulfinamido)-2,2,2-trifluoroethyl]malonate

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Technology Process of (R)-dibenzyl 2-[(S)-1-(tert-butanesulfinamido)-2,2,2-trifluoroethyl]malonate

There total 2 articles about (R)-dibenzyl 2-[(S)-1-(tert-butanesulfinamido)-2,2,2-trifluoroethyl]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1219607-83-6
(S_S)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide

: 15014-25-2
malonic acid dibenzyl ester

: 1372420-85-3
(R)-dibenzyl 2-[(S)-1-(tert-butanesulfinamido)-2,2,2-trifluoroethyl]malonate

Guidance literature:: malonic acid dibenzyl ester; With n-butyllithium; In hexane; toluene; at -78 ℃; for 0.166667h; Inert atmosphere;

(S_S)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide; In hexane; toluene; at -78 ℃; for 0.25h; stereoselective reaction; Inert atmosphere;
DOI:10.1039/c3ob42425a

Reference yield: 78.0%

: 1219607-83-6
(S_S)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide

: 15014-25-2
malonic acid dibenzyl ester

: 1372420-74-0
(S)-dibenzyl 2-[(S)-1-(tert-butanesulfinamido)-2,2,2-trifluoroethyl]malonate

: 1372420-85-3
(R)-dibenzyl 2-[(S)-1-(tert-butanesulfinamido)-2,2,2-trifluoroethyl]malonate

Guidance literature:: malonic acid dibenzyl ester; With 1-ethyl-2,2,4,4,4-pentakis(dimethylamino)-2λ⁵,4λ⁵-catenadi(phosphazene); In toluene; at -78 ℃; for 0.166667h; Inert atmosphere;

(S_S)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide; In toluene; at -78 ℃; for 24h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1039/c2cc30627a