7,7'-bis-benzyl-1,1'-ethylenebis(1,7-diaza-4,10-dioxacyclododecane)

Base Information

• Chemical Name: 7,7'-bis-benzyl-1,1'-ethylenebis(1,7-diaza-4,10-dioxacyclododecane)
• CAS No.: 80639-64-1
• Molecular Formula: C₃₂H₅₀N₄O₄
• Molecular Weight: 554.773
• Mol file: 80639-64-1.mol

Synonyms:7,7'-bis-benzyl-1,1'-ethylenebis(1,7-diaza-4,10-dioxacyclododecane)

Chemical Property of 7,7'-bis-benzyl-1,1'-ethylenebis(1,7-diaza-4,10-dioxacyclododecane)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7,7'-bis-benzyl-1,1'-ethylenebis(1,7-diaza-4,10-dioxacyclododecane)

There total 5 articles about 7,7'-bis-benzyl-1,1'-ethylenebis(1,7-diaza-4,10-dioxacyclododecane) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1,2-bis-tosyloxyethane (6315-52-2) + N-benzyl-1,7-diaza-4,10-dioxacyclododecane (80639-63-0) → 7,7'-bis-benzyl-1,1'-ethylenebis(1,7-diaza-4,10-dioxacyclododecane) (80639-64-1)

Guidance literature:

With sodium carbonate; In acetonitrile; for 48h; Heating;

DOI:10.1039/c39920000331

Reference yield:

N,N-bis<2-(2-hydroxyethoxy)ethyl>-4-methylbenzenesulfonamide (72358-83-9,63413-83-2) → 7,7'-bis-benzyl-1,1'-ethylenebis(1,7-diaza-4,10-dioxacyclododecane) (80639-64-1)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine

2: Na₂CO₃ / acetonitrile / 48 h / Heating

3: 91 percent / LiAlH₄ / tetrahydrofuran

4: Na₂CO₃ / acetonitrile / 48 h / Heating

With lithium aluminium tetrahydride; sodium carbonate; In tetrahydrofuran; pyridine; acetonitrile;

DOI:10.1039/c39810001084

Reference yield:

6-<(4-methylphenyl)sulfonyl>-3,9-dioxa-6-aza-1,11-undecanediol bis(methanesulfonate) (80639-61-8) → 7,7'-bis-benzyl-1,1'-ethylenebis(1,7-diaza-4,10-dioxacyclododecane) (80639-64-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Na₂CO₃ / acetonitrile / 48 h / Heating

2: 91 percent / LiAlH₄ / tetrahydrofuran

3: Na₂CO₃ / acetonitrile / 48 h / Heating

With lithium aluminium tetrahydride; sodium carbonate; In tetrahydrofuran; acetonitrile;

DOI:10.1039/c39810001084

upstream raw materials:

1,2-bis-tosyloxyethane

N-benzyl-1,7-diaza-4,10-dioxacyclododecane

N,N-bis<2-(2-hydroxyethoxy)ethyl>-4-methylbenzenesulfonamide

10-benzyl-4-<(4-methylphenyl)sulfonyl>-1,7-dioxa-4,10-diazacyclododecane