trimethyl(3-(2-(phenylethynyl)phenyl)-1-m-tolylpropa-1,2-dienyl)silane

Base Information

Chemical Name:trimethyl(3-(2-(phenylethynyl)phenyl)-1-m-tolylpropa-1,2-dienyl)silane
CAS No.:1422529-06-3
Molecular Formula:C₂₇H₂₆Si
Molecular Weight:378.589
Hs Code.:

Synonyms:trimethyl(3-(2-(phenylethynyl)phenyl)-1-m-tolylpropa-1,2-dienyl)silane

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Chemical Property of trimethyl(3-(2-(phenylethynyl)phenyl)-1-m-tolylpropa-1,2-dienyl)silane

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Technology Process of trimethyl(3-(2-(phenylethynyl)phenyl)-1-m-tolylpropa-1,2-dienyl)silane

There total 5 articles about trimethyl(3-(2-(phenylethynyl)phenyl)-1-m-tolylpropa-1,2-dienyl)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1252926-35-4
1-[2-(phenylethynyl)phenyl]-3-(trimethylsilyl)prop-2-yn-1-yl acetate

: 28987-79-3
m-tolylmagnesium bromide

: 1422529-06-3
trimethyl(3-(2-(phenylethynyl)phenyl)-1-m-tolylpropa-1,2-dienyl)silane

Guidance literature:: m-tolylmagnesium bromide; With zinc(II) chloride; In tetrahydrofuran; diethyl ether; at 20 ℃; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; at -60 ℃; for 0.25h;

1-[2-(phenylethynyl)phenyl]-3-(trimethylsilyl)prop-2-yn-1-yl acetate; In tetrahydrofuran; diethyl ether; for 14h;
DOI:10.1021/jo302524a

Reference yield:

: 536-74-3
phenylacetylene

: 1422529-06-3
trimethyl(3-(2-(phenylethynyl)phenyl)-1-m-tolylpropa-1,2-dienyl)silane

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 16 h / 20 °C / Inert atmosphere

2.1: ethylmagnesium bromide / tetrahydrofuran / 0.25 h / 0 - 20 °C / Inert atmosphere

2.2: 0.25 h / 20 °C / Inert atmosphere

3.1: triethylamine; dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.1: zinc(II) chloride / tetrahydrofuran; diethyl ether / 20 °C / Inert atmosphere

4.2: 0.25 h / -60 °C

4.3: 14 h

With dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ethylmagnesium bromide; triethylamine; zinc(II) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; 1.1: |Sonogashira Cross-Coupling / 2.2: |Grignard Reaction;
DOI:10.1021/jo302524a

Reference yield:

: 879286-37-0
3-(trimethylsilyl)-1-[2-(2-phenylethynyl)phenyl]prop-2-yn-1-ol

: 1422529-06-3
trimethyl(3-(2-(phenylethynyl)phenyl)-1-m-tolylpropa-1,2-dienyl)silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.1: zinc(II) chloride / tetrahydrofuran; diethyl ether / 20 °C / Inert atmosphere

2.2: 0.25 h / -60 °C

2.3: 14 h

With dmap; triethylamine; zinc(II) chloride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo302524a