benzyl (3-((((3aR,4R,6R,6aR)-6-(6-amino-911-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)cyclobutyl)carbamate

Base Information

Chemical Name:benzyl (3-((((3aR,4R,6R,6aR)-6-(6-amino-911-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)cyclobutyl)carbamate
CAS No.:1380350-54-8
Molecular Formula:C₂₆H₃₃N₇O₅
Molecular Weight:523.592
Hs Code.:

Synonyms:benzyl (3-((((3aR,4R,6R,6aR)-6-(6-amino-911-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)cyclobutyl)carbamate

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Chemical Property of benzyl (3-((((3aR,4R,6R,6aR)-6-(6-amino-911-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)cyclobutyl)carbamate

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Technology Process of benzyl (3-((((3aR,4R,6R,6aR)-6-(6-amino-911-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)cyclobutyl)carbamate

There total 2 articles about benzyl (3-((((3aR,4R,6R,6aR)-6-(6-amino-911-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 130369-36-7
N-(Benzyloxycarbonyl)-3-amino-1-cyclobutanone

: 34245-49-3
5'-deoxy-5'-methylamino-2',3'-O,O-(1-methylethylidene)adenosine

: 1380350-54-8
benzyl (3-((((3aR,4R,6R,6aR)-6-(6-amino-911-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)cyclobutyl)carbamate

Guidance literature:: With titanium(IV) isopropylate; In methanol;

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1380350-54-8
benzyl (3-((((3aR,4R,6R,6aR)-6-(6-amino-911-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; diphenylphosphoranyl azide / toluene / 3 h / 60 °C / Inert atmosphere

1.2: 60 °C

2.1: titanium(IV) isopropylate / methanol

With titanium(IV) isopropylate; diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine; In methanol; toluene;

Reference yield:

: 1380350-54-8
benzyl (3-((((3aR,4R,6R,6aR)-6-(6-amino-911-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)cyclobutyl)carbamate

: 1380349-97-2
1-(3-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)cyclobutyl)-3-(4-tert-butylphenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; palladium(II) hydroxide / methanol / 5 h / 35 °C

2.1: triethylamine / dichloromethane; tetrahydrofuran / 1 h / 20 °C

3.1: trifluoroacetic acid / water / 1 h / 20 °C

3.2: 0.5 h

With hydrogen; palladium(II) hydroxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;