N-[2-methyl-5-(4-methyl-6-morpholin-4-yl-pyrimidin-5-ylethynyl)-pyridin-3-yl]-2-trifluoromethylbenzenesulfonamide

Base Information

Chemical Name:N-[2-methyl-5-(4-methyl-6-morpholin-4-yl-pyrimidin-5-ylethynyl)-pyridin-3-yl]-2-trifluoromethylbenzenesulfonamide
CAS No.:1391978-07-6
Molecular Formula:C₂₄H₂₂F₃N₅O₃S
Molecular Weight:517.532
Hs Code.:

Synonyms:N-[2-methyl-5-(4-methyl-6-morpholin-4-yl-pyrimidin-5-ylethynyl)-pyridin-3-yl]-2-trifluoromethylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-methyl-5-(4-methyl-6-morpholin-4-yl-pyrimidin-5-ylethynyl)-pyridin-3-yl]-2-trifluoromethylbenzenesulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[2-methyl-5-(4-methyl-6-morpholin-4-yl-pyrimidin-5-ylethynyl)-pyridin-3-yl]-2-trifluoromethylbenzenesulfonamide

There total 12 articles about N-[2-methyl-5-(4-methyl-6-morpholin-4-yl-pyrimidin-5-ylethynyl)-pyridin-3-yl]-2-trifluoromethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1391979-33-1
2-methyl-5-(4-methyl-6-morpholin-4-ylpyrimidin-5-ylethynyl)pyridin-3-ylamine

: 776-04-5
2-trifluoromethylbenzenesulfonyl chloride

: 1391978-07-6
N-[2-methyl-5-(4-methyl-6-morpholin-4-yl-pyrimidin-5-ylethynyl)-pyridin-3-yl]-2-trifluoromethylbenzenesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1391978-07-6
N-[2-methyl-5-(4-methyl-6-morpholin-4-yl-pyrimidin-5-ylethynyl)-pyridin-3-yl]-2-trifluoromethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 2 h / 0 - 50 °C

2.1: hydrogenchloride / water / 3 h / Reflux

3.1: ammonium chloride; iron / ethanol / 3 h / Reflux

4.1: diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 100 °C / Inert atmosphere

5.1: potassium carbonate; methanol / 3 h / 20 °C

6.1: diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / dimethyl sulfoxide / 65 °C / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; 1-methyl-pyrrolidin-2-one / 80 °C

8.1: pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; methanol; iron; sodium hydride; potassium carbonate; ammonium chloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 911434-04-3
2-(5-bromo-3-nitro-pyridin-2-yl)-malonic acid diethyl ester

: 1391978-07-6
N-[2-methyl-5-(4-methyl-6-morpholin-4-yl-pyrimidin-5-ylethynyl)-pyridin-3-yl]-2-trifluoromethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / water / 3 h / Reflux

2: ammonium chloride; iron / ethanol / 3 h / Reflux

3: diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 100 °C / Inert atmosphere

4: potassium carbonate; methanol / 3 h / 20 °C

5: diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / dimethyl sulfoxide / 65 °C / Inert atmosphere

6: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; 1-methyl-pyrrolidin-2-one / 80 °C

7: pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; methanol; iron; potassium carbonate; ammonium chloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide;