2-[(2R,4R)-4-Hydroxy-9-(4-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-2-yl]-N-(2-phenylsulfanyl-ethyl)-acetamide

Base Information

Chemical Name:2-[(2R,4R)-4-Hydroxy-9-(4-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-2-yl]-N-(2-phenylsulfanyl-ethyl)-acetamide
CAS No.:137333-46-1
Molecular Formula:C₂₉H₃₀N₂O₅S₂
Molecular Weight:550.7
Hs Code.:

Synonyms:2-[(2R,4R)-4-Hydroxy-9-(4-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-2-yl]-N-(2-phenylsulfanyl-ethyl)-acetamide

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Chemical Property of 2-[(2R,4R)-4-Hydroxy-9-(4-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-2-yl]-N-(2-phenylsulfanyl-ethyl)-acetamide

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Technology Process of 2-[(2R,4R)-4-Hydroxy-9-(4-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-2-yl]-N-(2-phenylsulfanyl-ethyl)-acetamide

There total 9 articles about 2-[(2R,4R)-4-Hydroxy-9-(4-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-2-yl]-N-(2-phenylsulfanyl-ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 137333-45-0
N-<2'-(phenylthio)ethyl>-1,2,3,4-tetrahydro-4-oxo-9-<(p-methoxyphenyl)sulfonyl>carbazole-2-acetamide

: 137333-46-1
2-[(2R,4R)-4-Hydroxy-9-(4-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-2-yl]-N-(2-phenylsulfanyl-ethyl)-acetamide

Guidance literature:: With sodium tetrahydroborate; In methanol; at 21 ℃; for 1h;
DOI:10.1021/jo00027a016

Reference yield:

: 2014-75-7
2-(phenylthio)ethanamine

: 137333-46-1
2-[(2R,4R)-4-Hydroxy-9-(4-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-2-yl]-N-(2-phenylsulfanyl-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) triethylamine / 1.) methylene dichloride, 0 deg C, 2 h 2.) THF, 25 deg C, 12 h

2: 100 percent / sodium borohydride / methanol / 1 h / 21 °C

With sodium tetrahydroborate; triethylamine; In methanol;
DOI:10.1021/jo00027a016

Reference yield:

: 137333-34-7,137333-35-8,39762-51-1
(3-Oxo-cyclohexyl)-acetic Acid

: 137333-46-1
2-[(2R,4R)-4-Hydroxy-9-(4-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-2-yl]-N-(2-phenylsulfanyl-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 73 percent / aq. acetic acid / 10 h / Heating

2: 99.6 percent / concd HCl, dimethoxypropane / 2 h / 20 °C

3: 85 percent / dichlorodicyanoquinone / tetrahydrofuran; H₂O / 2 h / 0 °C

4: tetra-N-benzylammonium chloride, 30percent NaOH / CH₂Cl₂ / 1 h

5: aq. lithium hydroxide / tetrahydrofuran / 1 h / 23 °C

6: 1.) triethylamine / 1.) methylene dichloride, 0 deg C, 2 h 2.) THF, 25 deg C, 12 h

7: 100 percent / sodium borohydride / methanol / 1 h / 21 °C

With hydrogenchloride; lithium hydroxide; sodium hydroxide; sodium tetrahydroborate; Bn₄NCl; dimethoxypropane; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo00027a016