2,4-dichloro-6-<1-(4-fluorophenyl)-3-(4-fluorophenoxy)-1-propyl>phenol

Base Information

Chemical Name:2,4-dichloro-6-<1-(4-fluorophenyl)-3-(4-fluorophenoxy)-1-propyl>phenol
CAS No.:110723-74-5
Molecular Formula:C₂₁H₁₆Cl₂F₂O₂
Molecular Weight:409.26
Hs Code.:

Synonyms:2,4-dichloro-6-<1-(4-fluorophenyl)-3-(4-fluorophenoxy)-1-propyl>phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,4-dichloro-6-<1-(4-fluorophenyl)-3-(4-fluorophenoxy)-1-propyl>phenol

Chemical Property:

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Technology Process of 2,4-dichloro-6-<1-(4-fluorophenyl)-3-(4-fluorophenoxy)-1-propyl>phenol

There total 11 articles about 2,4-dichloro-6-<1-(4-fluorophenyl)-3-(4-fluorophenoxy)-1-propyl>phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 136007-79-9
1-(benzyloxy)-2,4-dichloro-6-<3-(1-fluorophenyl)-3-(4-fluorophenoxy)-1-propyl>benzene

: 110723-74-5
2,4-dichloro-6-<1-(4-fluorophenyl)-3-(4-fluorophenoxy)-1-propyl>phenol

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In acetic acid; at 25 ℃; for 0.333333h; under 750.06 Torr;
DOI:10.1021/jm00114a004

Reference yield:

: 371-41-5
4-Fluorophenol

: 110723-74-5
2,4-dichloro-6-<1-(4-fluorophenyl)-3-(4-fluorophenoxy)-1-propyl>phenol

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / dimethylsulfoxide / 4 h / 50 °C

2: 99 percent / H₂, conc. HCl / 10percent Pd/C / acetic acid / 0.33 h / 25 °C / 750.06 Torr

With hydrogenchloride; hydrogen; palladium on activated charcoal; In acetic acid; dimethyl sulfoxide;
DOI:10.1021/jm00114a004

Reference yield:

: 6992-87-6
1-(4-fluorophenyl)-3-bromoprop-1-ene

: 110723-74-5
2,4-dichloro-6-<1-(4-fluorophenyl)-3-(4-fluorophenoxy)-1-propyl>phenol

Guidance literature:: Multi-step reaction with 8 steps

1: 79 percent / K₂CO₃ / acetone / 4 h / Heating

2: 84 percent / N,N-dimethylaniline / bis-(2-methoxy-ethyl) ether / 10 h / 160 °C

3: K₂CO₃ / dimethylformamide / 8 h / 70 - 75 °C

4: 1.) 9-BBN, 2.) 2N aq. NaOH, H₂O₂ / 1.) THF, a) 20 deg C, 30 min, b) reflux, 90 min, 2.) THF, reflux, 1 h

5: 91 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

6: 70 percent / NaI / acetone / 4 h / Heating

7: 76 percent / dimethylsulfoxide / 4 h / 50 °C

8: 99 percent / H₂, conc. HCl / 10percent Pd/C / acetic acid / 0.33 h / 25 °C / 750.06 Torr

With pyridine; hydrogenchloride; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; hydrogen; dihydrogen peroxide; potassium carbonate; N,N-dimethyl-aniline; sodium iodide; palladium on activated charcoal; In dichloromethane; diethylene glycol dimethyl ether; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00114a004