17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester

Base Information

• Chemical Name: 17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester
• CAS No.: 36193-50-7
• Molecular Formula: C₂₂H₂₈N₂O₄
• Molecular Weight: 384.475
• Mol file: 36193-50-7.mol

Synonyms:17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester

Chemical Property of 17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester

There total 2 articles about 17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S,4aR,8aR,13bS,14aS)-8a-Chloro-2-hydroxy-1,2,3,4,4a,5,7,8,8a,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (94992-42-4) → (+)-3,14-didehydroyohimbine (90362-85-9) + 17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester (71748-23-7) + 17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester (36193-50-7) + Yohimbine (146-48-5)

Guidance literature:

With sodium methylate; In methanol; for 0.666667h; Further byproducts given. Title compound not separated from byproducts; Heating;

DOI:10.1002/hlca.19960790510

Reference yield:

(1R,2S,4aR,8aR,13bS,14aS)-8a-Chloro-2-hydroxy-1,2,3,4,4a,5,7,8,8a,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (94992-42-4) → 3,4,5,6-tetradehydroyohimbine + (+)-3,14-didehydroyohimbine (90362-85-9) + 17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester (71748-23-7) + 17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester (36193-50-7) + Yohimbine (146-48-5)

Guidance literature:

With sodium methylate; In methanol; for 0.666667h; Product distribution; Equilibrium constant; Mechanism; Heating; solvolysis by KOH, MeOH, NaOMe;

DOI:10.1002/hlca.19960790510

Reference yield: 86.0%

17-hydroxy-2-methoxy-17,18-cyclo-corynox-1-ene-16-carboxylic acid methyl ester (36193-50-7) → yohombine oxindole A (5074-58-8)

Guidance literature:

With trifluoroacetic acid; for 3.5h; Heating;

DOI:10.1002/hlca.19960790510

upstream raw materials:

(1R,2S,4aR,8aR,13bS,14aS)-8a-Chloro-2-hydroxy-1,2,3,4,4a,5,7,8,8a,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester

Downstream raw materials:

yohimbine oxindole B

yohombine oxindole A