N-[[1-[(2,5-dimethylphenyl)acetyl]-4-piperidinyl]carbonyl]-DL-serine methyl ester

Base Information

Chemical Name:N-[[1-[(2,5-dimethylphenyl)acetyl]-4-piperidinyl]carbonyl]-DL-serine methyl ester
CAS No.:922516-14-1
Molecular Formula:C₂₀H₂₈N₂O₅
Molecular Weight:376.453
Hs Code.:

Synonyms:N-[[1-[(2,5-dimethylphenyl)acetyl]-4-piperidinyl]carbonyl]-DL-serine methyl ester

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Chemical Property of N-[[1-[(2,5-dimethylphenyl)acetyl]-4-piperidinyl]carbonyl]-DL-serine methyl ester

Chemical Property:

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Technology Process of N-[[1-[(2,5-dimethylphenyl)acetyl]-4-piperidinyl]carbonyl]-DL-serine methyl ester

There total 4 articles about N-[[1-[(2,5-dimethylphenyl)acetyl]-4-piperidinyl]carbonyl]-DL-serine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 922516-13-0
1-[(2,5-dimethylphenyl)acetyl]-4-piperidinecarboxylic acid

: 5619-04-5
methyl 2-amino-3-hydroxypropanoate hydrochloride

: 922516-14-1
N-[[1-[(2,5-dimethylphenyl)acetyl]-4-piperidinyl]carbonyl]-DL-serine methyl ester

Guidance literature:: 1-[(2,5-dimethylphenyl)acetyl]-4-piperidinecarboxylic acid; With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.25h;

methyl 2-amino-3-hydroxypropanoate hydrochloride; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 13612-34-5
2-(2,5-dimethylphenyl)acetic acid

: 922516-14-1
N-[[1-[(2,5-dimethylphenyl)acetyl]-4-piperidinyl]carbonyl]-DL-serine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

2.1: triethylamine / dichloromethane / 16 h / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

4.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 20 °C

4.2: 16 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; oxalyl dichloride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 922516-12-9
methyl 1-[(2,5-dimethylphenyl)acetyl]-4-piperidine-carboxylate

: 922516-14-1
N-[[1-[(2,5-dimethylphenyl)acetyl]-4-piperidinyl]carbonyl]-DL-serine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

2.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 20 °C

2.2: 16 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;