diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylbenzyl)phenylamino]methylphosphonate

Base Information

Chemical Name:diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylbenzyl)phenylamino]methylphosphonate
CAS No.:852949-75-8
Molecular Formula:C₂₃H₃₄NO₄P
Molecular Weight:419.501
Hs Code.:

Synonyms:diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylbenzyl)phenylamino]methylphosphonate

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Chemical Property of diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylbenzyl)phenylamino]methylphosphonate

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Technology Process of diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylbenzyl)phenylamino]methylphosphonate

There total 3 articles about diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylbenzyl)phenylamino]methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 852949-74-7
diethyl N-t-butoxycarbonyl-[3,5-dimethyl-4-(4'-methoxymethoxy-3'-iso-propylbenzyl)phenylamino]methylphosphonate

: 852949-75-8
diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylbenzyl)phenylamino]methylphosphonate

Guidance literature:: diethyl N-t-butoxycarbonyl-[3,5-dimethyl-4-(4'-methoxymethoxy-3'-iso-propylbenzyl)phenylamino]methylphosphonate; With hydrogenchloride; water; In methanol; at 0 - 20 ℃; for 48h;

With sodium hydrogencarbonate; In methanol; at 0 ℃;

Reference yield:

: 848442-44-4
trifluoromethanesulfonic acid 4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenyl ester

: 852949-75-8
diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylbenzyl)phenylamino]methylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis(diphenyl-phosphino)propane; triethylamine / palladium diacetate / N,N-dimethyl-formamide / 16 h / 90 °C / 3102.97 Torr

2.1: sodium hydroxide; water / methanol / 16 h / 50 °C

2.2: 0 °C

3.1: diphenylphosphoranyl azide; triethylamine / toluene / 16 h / Heating / reflux

4.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.33 h / -78 °C

4.2: 5 h / -78 - 20 °C

5.1: hydrogenchloride; water / methanol / 48 h / 20 °C

With hydrogenchloride; sodium hydroxide; bis(diphenyl-phosphino)propane; diphenylphosphoranyl azide; water; triethylamine; lithium diisopropyl amide; palladium diacetate; In tetrahydrofuran; methanol; n-heptane; ethylbenzene; N,N-dimethyl-formamide; toluene;

Reference yield:

: 852949-72-5
3,5-dimethyl-4-(4'-methoxymethoxy-3'-iso-propylbenzyl)benzoic acid

: 852949-75-8
diethyl [3,5-dimethyl-4-(4'-hydroxy-3'-iso-propylbenzyl)phenylamino]methylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenylphosphoranyl azide; triethylamine / toluene / 16 h / Heating / reflux

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.33 h / -78 °C

2.2: 5 h / -78 - 20 °C

3.1: hydrogenchloride; water / methanol / 48 h / 20 °C

With hydrogenchloride; diphenylphosphoranyl azide; water; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; n-heptane; ethylbenzene; toluene;