(1R,2S,4R,12aR)-2-fluoro-7-hydroxy-6,8-dioxo-N-(2,4,6-trifluorobenzyl)-1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazine-9-carboxamide

Base Information

Chemical Name:(1R,2S,4R,12aR)-2-fluoro-7-hydroxy-6,8-dioxo-N-(2,4,6-trifluorobenzyl)-1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazine-9-carboxamide
CAS No.:1616340-22-7
Molecular Formula:C₂₁H₁₇F₄N₃O₄
Molecular Weight:451.377
Hs Code.:

(1R,2S,4R,12aR)-2-fluoro-7-hydroxy-6,8-dioxo-N-(2,4,6-trifluorobenzyl)-1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazine-9-carboxamide

Synonyms:(1R,2S,4R,12aR)-2-fluoro-7-hydroxy-6,8-dioxo-N-(2,4,6-trifluorobenzyl)-1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazine-9-carboxamide

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Chemical Property of (1R,2S,4R,12aR)-2-fluoro-7-hydroxy-6,8-dioxo-N-(2,4,6-trifluorobenzyl)-1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazine-9-carboxamide

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Technology Process of (1R,2S,4R,12aR)-2-fluoro-7-hydroxy-6,8-dioxo-N-(2,4,6-trifluorobenzyl)-1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazine-9-carboxamide

There total 12 articles about (1R,2S,4R,12aR)-2-fluoro-7-hydroxy-6,8-dioxo-N-(2,4,6-trifluorobenzyl)-1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazine-9-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616341-10-6
C₂₈H₂₃F₄N₃O₄

: 1616340-22-7
(1R,2S,4R,12aR)-2-fluoro-7-hydroxy-6,8-dioxo-N-(2,4,6-trifluorobenzyl)-1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazine-9-carboxamide

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 0.166667h;

Reference yield:

: 1656286-96-2
C₂₄H₃₁NO₃Si

: 1616340-22-7
(1R,2S,4R,12aR)-2-fluoro-7-hydroxy-6,8-dioxo-N-(2,4,6-trifluorobenzyl)-1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazine-9-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h

2.1: lithium borohydride / tetrahydrofuran / 18 h / 20 °C / Cooling with ice

3.1: phthalimide; triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 h / 20 °C / Cooling with ice

3.2: 2 h / 70 °C

4.1: sodium hydrogencarbonate / ethanol; water / 20 h

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1.5 h

5.2: 0.58 h / 110 °C

6.1: potassium hydroxide; methanol / tetrahydrofuran / 0.5 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1.5 h

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice

8.2: 1 h / -78 - 20 °C

9.1: trifluoroacetic acid / 0.17 h / 20 °C

With hydrogenchloride; methanol; lithium borohydride; phthalimide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 1616341-02-6
C₁₆H₂₁NO₃

: 1616340-22-7
(1R,2S,4R,12aR)-2-fluoro-7-hydroxy-6,8-dioxo-N-(2,4,6-trifluorobenzyl)-1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazine-9-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h

2.1: hydrogen; 10% palladium hydroxide on charcoal / ethanol; acetic acid / 40 h / 38002.6 Torr

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h

4.1: lithium borohydride / tetrahydrofuran / 18 h / 20 °C / Cooling with ice

5.1: phthalimide; triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 h / 20 °C / Cooling with ice

5.2: 2 h / 70 °C

6.1: sodium hydrogencarbonate / ethanol; water / 20 h

7.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1.5 h

7.2: 0.58 h / 110 °C

8.1: potassium hydroxide; methanol / tetrahydrofuran / 0.5 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1.5 h

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice

10.2: 1 h / -78 - 20 °C

11.1: trifluoroacetic acid / 0.17 h / 20 °C

With 1H-imidazole; hydrogenchloride; methanol; lithium borohydride; phthalimide; di-isopropyl azodicarboxylate; 10% palladium hydroxide on charcoal; tetrabutyl ammonium fluoride; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;