N-[(2R,3R,4R,5R)-3-Hydroxy-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2-[(2S,3R,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide

Base Information

Chemical Name:N-[(2R,3R,4R,5R)-3-Hydroxy-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2-[(2S,3R,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide
CAS No.:171762-64-4
Molecular Formula:C₂₃H₃₁N₅O₁₀
Molecular Weight:537.527
Hs Code.:

N-[(2R,3R,4R,5R)-3-Hydroxy-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2-[(2S,3R,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide

Synonyms:N-[(2R,3R,4R,5R)-3-Hydroxy-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2-[(2S,3R,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide

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Chemical Property of N-[(2R,3R,4R,5R)-3-Hydroxy-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2-[(2S,3R,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide

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Technology Process of N-[(2R,3R,4R,5R)-3-Hydroxy-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2-[(2S,3R,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide

There total 1 articles about N-[(2R,3R,4R,5R)-3-Hydroxy-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2-[(2S,3R,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55486-09-4
2'-O-Methyl-5-methyluridine

: 171762-64-4
N-[(2R,3R,4R,5R)-3-Hydroxy-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2-[(2S,3R,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / I₂, PPh₃, pyridine / 5 h / Ambient temperature

2: 89 percent / NaN₃ / dimethylformamide / 24 h / 60 °C

3: 87 percent / DMAP, imidazole / dimethylformamide / 24 h / Ambient temperature

4: 72 percent / SnCl₂*2H₂O / methanol / 20 h / Ambient temperature

5: 1.) Et₃N, O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, HOBT, 2.) Et₃N / 1.) MeCN, THF, r.t., 1 h, 2.) r.t., 12 h

6: 95 percent / TBAF / tetrahydrofuran / 9 h / Ambient temperature

With pyridine; 1H-imidazole; dmap; sodium azide; tetrabutyl ammonium fluoride; iodine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; triphenylphosphine; tin(ll) chloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield: 78.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 171762-64-4
N-[(2R,3R,4R,5R)-3-Hydroxy-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2-[(2S,3R,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide

: 171762-61-1
C₄₄H₄₉N₅O₁₂

Guidance literature:: With pyridine; for 24h; Ambient temperature;

Reference yield:

: 171762-64-4
N-[(2R,3R,4R,5R)-3-Hydroxy-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2-[(2S,3R,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide

: C₅₃H₆₆N₇O₁₃P

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / pyridine / 24 h / Ambient temperature

2: 71 percent / diisopropylammonium tetrazolide / CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; N,N-diisopropylamine tetrazolide; In dichloromethane;