Technology Process of 2-ethyl-3-hydroxy-17β-tert-butyldiphenylsilyloxymethylestra-1,3,5(10)-triene
There total 5 articles about 2-ethyl-3-hydroxy-17β-tert-butyldiphenylsilyloxymethylestra-1,3,5(10)-triene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 24h;
DOI:10.1021/jm200483x
- Guidance literature:
-
Multi-step reaction with 5 steps
1: titanium tetrachloride; magnesium / 0 - 20 °C
2: tetrahydrofuran / 5 h / 0 °C
3: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 2 h / 0 °C
4: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C
5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 24 h / 20 °C
With
1H-imidazole; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; titanium tetrachloride; magnesium; sodium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
2: Hydroboration reaction;
DOI:10.1021/jm200483x
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 2 h / 0 °C
2: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C
3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 24 h / 20 °C
With
1H-imidazole; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200483x
