ditert-butyl(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)fluorosilane

Base Information

• Chemical Name: ditert-butyl(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)fluorosilane
• CAS No.: 1353987-81-1
• Molecular Formula: C₂₁H₃₉FOSi₂
• Molecular Weight: 382.709
• Mol file: 1353987-81-1.mol

Synonyms:ditert-butyl(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)fluorosilane

Chemical Property of ditert-butyl(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)fluorosilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ditert-butyl(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)fluorosilane

There total 1 articles about ditert-butyl(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)fluorosilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

di-tert-butyldifluorosilane (558-63-4) + [(3-bromobenzyl)oxy](tert-butyl)dimethylsilane (103978-12-7) → ditert-butyl(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)fluorosilane (1353987-81-1)

Guidance literature:

[(3-bromobenzyl)oxy](tert-butyl)dimethylsilane; With tert.-butyl lithium; In tetrahydrofuran; Cyclopentane; pentane; at -78 ℃; for 0.5h;

di-tert-butyldifluorosilane; In tetrahydrofuran; Cyclopentane; pentane; at -78 - 20 ℃;

DOI:10.1016/j.bmc.2013.04.029

Reference yield: 65.0%

ditert-butyl(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)fluorosilane (1353987-81-1) → 3-(ditert-butylfluorosilyl)benzyl alcohol (1353987-82-2)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃;

DOI:10.1016/j.bmc.2013.04.029

Reference yield:

ditert-butyl(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)fluorosilane (1353987-81-1) → 3-(ditert-butylfluorosilyl)benzaldehyde (1353987-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / methanol; water / 20 °C

2: pyridinium chlorochromate / dichloromethane / 3 h / 0 - 20 °C

With hydrogenchloride; pyridinium chlorochromate; In methanol; dichloromethane; water;

DOI:10.1016/j.bmc.2013.04.029

upstream raw materials:

di-tert-butyldifluorosilane

[(3-bromobenzyl)oxy](tert-butyl)dimethylsilane

Downstream raw materials:

3-(ditert-butylfluorosilyl)benzyl alcohol

3-(ditert-butylfluorosilyl)benzaldehyde

N-succinimidyl 3-(di-tert-butylfluorosilyl)benzoate

3-(ditert-butylfluorosilyl)-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)benzamide