5,6-dichloro-1-methyl-1H-Benzimidazole

Base Information

• Chemical Name: 5,6-dichloro-1-methyl-1H-Benzimidazole
• CAS No.: 6478-75-7
• Molecular Formula: C₈H₆Cl₂N₂
• Molecular Weight: 201.055
• DSSTox Substance ID: DTXSID101283993
• Mol file: 6478-75-7.mol

Synonyms:SCHEMBL2625812;DTXSID101283993;5,6-dichloro-1-methyl-1H-Benzimidazole;6478-75-7

Chemical Property of 5,6-dichloro-1-methyl-1H-Benzimidazole

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 199.9908036
• Heavy Atom Count: 12
• Complexity: 176

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1C=NC2=CC(=C(C=C21)Cl)Cl

Technology Process of 5,6-dichloro-1-methyl-1H-Benzimidazole

There total 1 articles about 5,6-dichloro-1-methyl-1H-Benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

5,6-dichloro-1-ethoxycarbonyl-3-methyl-benzimidazolium tetrafluoroborate → 5,6-dichloro-1-methylbenzimidazole (6478-75-7) + [4,5-Dichloro-2-(formyl-methyl-amino)-phenyl]-carbamic acid ethyl ester

Guidance literature:

With oxygen; tetraethylammonium perchlorate; In acetonitrile; for 3h; Ambient temperature; electrolysis;

DOI:10.1016/0040-4020(96)00313-4

Reference yield: 86.0%

5,6-dichloro-1-methylbenzimidazole (6478-75-7) + orthoformic acid triethyl ester (122-51-0) + aniline (62-53-3) → C21H17N4(1+)*Cl(1-) (1013424-94-6)

Guidance literature:

5,6-dichloro-1-methylbenzimidazole; aniline; With sodium t-butanolate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; palladium diacetate; In toluene; at 120 ℃; for 12h;

orthoformic acid triethyl ester; With hydrogenchloride; In toluene; at 150 ℃; for 12h; Further stages.;

DOI:10.1021/ja7102247

Downstream raw materials:

C₂₁H₁₇N₄⁽¹⁺⁾*Cl^(1-)