ethyl 7-acetoxy-8-methoxy-3,4-dihydro-4-oxopyrimido<4,5-b>quinoline-2-carboxylate p-toluenesulfonate

Base Information

Chemical Name:ethyl 7-acetoxy-8-methoxy-3,4-dihydro-4-oxopyrimido<4,5-b>quinoline-2-carboxylate p-toluenesulfonate
CAS No.:58662-71-8
Molecular Formula:C₇H₈O₃S*C₁₇H₁₅N₃O₆
Molecular Weight:529.527
Hs Code.:

Synonyms:ethyl 7-acetoxy-8-methoxy-3,4-dihydro-4-oxopyrimido<4,5-b>quinoline-2-carboxylate p-toluenesulfonate

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Chemical Property of ethyl 7-acetoxy-8-methoxy-3,4-dihydro-4-oxopyrimido<4,5-b>quinoline-2-carboxylate p-toluenesulfonate

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Technology Process of ethyl 7-acetoxy-8-methoxy-3,4-dihydro-4-oxopyrimido<4,5-b>quinoline-2-carboxylate p-toluenesulfonate

There total 4 articles about ethyl 7-acetoxy-8-methoxy-3,4-dihydro-4-oxopyrimido<4,5-b>quinoline-2-carboxylate p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 108-24-7
acetic anhydride

: 58662-61-6
ethyl 7-hydroxy-8-methoxy-3,4-dihydro-4-oxopyrimido<4,5-b>quinoline-2-carboxylate

: 58662-71-8
ethyl 7-acetoxy-8-methoxy-3,4-dihydro-4-oxopyrimido<4,5-b>quinoline-2-carboxylate p-toluenesulfonate

Guidance literature:: With toluene-4-sulfonic acid; at 100 ℃; for 24h;
DOI:10.1021/jm00177a010

Reference yield:

: 58662-55-8
2-amino-6-benzyloxy-7-methoxy-quinoline-3-carboxylic acid amide

: 58662-71-8
ethyl 7-acetoxy-8-methoxy-3,4-dihydro-4-oxopyrimido<4,5-b>quinoline-2-carboxylate p-toluenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 25 percent / xylene / 4 h / Heating

2: 72 percent / trifluoroacetic acid (TFAA) / 2.5 h / Heating

3: 58 percent / p-toluenesulfonic acid / 24 h / 100 °C

With toluene-4-sulfonic acid; trifluoroacetic acid; In xylene;
DOI:10.1021/jm00177a010

Reference yield:

: 58662-58-1
7-benzyloxy-8-methoxy-4-oxo-3,4-dihydro-pyrimido[4,5-b]quinoline-2-carboxylic acid ethyl ester

: 58662-71-8
ethyl 7-acetoxy-8-methoxy-3,4-dihydro-4-oxopyrimido<4,5-b>quinoline-2-carboxylate p-toluenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / trifluoroacetic acid (TFAA) / 2.5 h / Heating

2: 58 percent / p-toluenesulfonic acid / 24 h / 100 °C

With toluene-4-sulfonic acid; trifluoroacetic acid;
DOI:10.1021/jm00177a010